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dc.contributor.authorWadsley, J
dc.contributor.authorGregory, R
dc.contributor.authorFlux, G
dc.contributor.authorNewbold, K
dc.contributor.authorDu, Y
dc.contributor.authorMoss, L
dc.contributor.authorHall, A
dc.contributor.authorFlanagan, L
dc.contributor.authorBrown, SR
dc.date.accessioned2018-02-19T12:43:00Z
dc.date.issued2017-05
dc.identifier.citationThe British journal of radiology, 2017, 90 (1073), pp. 20160637 - ?
dc.identifier.issn0007-1285
dc.identifier.urihttps://repository.icr.ac.uk/handle/internal/1296
dc.identifier.eissn1748-880X
dc.identifier.doi10.1259/bjr.20160637
dc.description.abstractTreatment options for patients with thyroid cancer that is no longer sensitive to iodine therapy are limited. Those treatments which currently exist are associated with significant toxicity. The SELIMETRY trial (EudraCT No 2015-002269-47) aims to investigate the role of the MEK inhibitor Selumetinib in resensitizing advanced iodine refractory differentiated thyroid cancer to radioiodine therapy. Patients deemed to have sufficient iodine uptake in previously iodine refractory lesions after 4 weeks of Selumetinib therapy will be given an empirical activity of 5.5 GBq I-131, and response to therapy will be assessed. The trial presents an opportunity to investigate the dosimetric aspects of radioiodine therapy for advanced thyroid cancer. Patients will undergo serial I-123 single-photon emission CT (SPECT)/CT scans following Selumetinib therapy to determine whether there has been a change in the degree of iodine uptake to justify further I-131 therapy, and to allow dosimetric calculations to predict absorbed dose to target lesions following therapy. Patients receiving I-131 therapy will undergo a further series of post-therapy SPECT/CT scans to allow dosimetric calculations. We describe the challenges in setting up a multicentre trial in a relatively underinvestigated field, describing the work that has been carried out to calibrate and validate measurements to ensure that standardized image data are collected at each site. We hope that this trial will lead to individualization and optimization of therapy for patients with advanced thyroid cancer and that the ground work carried out in setting up a network of centres capable of standardized molecular radiotherapy dosimetry will lead to further clinical trials in this field.
dc.formatPrint-Electronic
dc.format.extent20160637 - ?
dc.languageeng
dc.language.isoeng
dc.rights.urihttps://creativecommons.org/licenses/by/4.0
dc.subjectHumans
dc.subjectThyroid Neoplasms
dc.subjectIodine Radioisotopes
dc.subjectBenzimidazoles
dc.subjectRadiopharmaceuticals
dc.subjectRadiotherapy Dosage
dc.subjectResearch Design
dc.titleSELIMETRY-a multicentre I-131 dosimetry trial: a clinical perspective.
dc.typeJournal Article
rioxxterms.versionofrecord10.1259/bjr.20160637
rioxxterms.licenseref.urihttps://creativecommons.org/licenses/by/4.0
rioxxterms.licenseref.startdate2017-05
rioxxterms.typeJournal Article/Review
dc.relation.isPartOfThe British journal of radiology
pubs.issue1073
pubs.notesNot known
pubs.organisational-group/ICR
pubs.organisational-group/ICR/Primary Group
pubs.organisational-group/ICR/Primary Group/ICR Divisions
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Radiotherapy and Imaging
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Radiotherapy and Imaging/Radioisotope Physics
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Radiotherapy and Imaging/Radioisotope Physics/Radioisotope Physics (hon.)
pubs.organisational-group/ICR/Primary Group/Royal Marsden Clinical Units
pubs.organisational-group/ICR
pubs.organisational-group/ICR/Primary Group
pubs.organisational-group/ICR/Primary Group/ICR Divisions
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Radiotherapy and Imaging
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Radiotherapy and Imaging/Radioisotope Physics
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Radiotherapy and Imaging/Radioisotope Physics/Radioisotope Physics (hon.)
pubs.organisational-group/ICR/Primary Group/Royal Marsden Clinical Units
pubs.publication-statusPublished
pubs.volume90
pubs.embargo.termsNot known
icr.researchteamRadioisotope Physicsen_US
dc.contributor.icrauthorFlux, Glennen
dc.contributor.icrauthorMarsden,en


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