Imaging and dosimetry for radium-223: the potential for personalized treatment.

View/ Open
Publication Date
2017-08Author
Flux, GD
Type
Journal Article
Metadata
Show full item recordAbstract
Radium-223 (<sup>223</sup>Ra) offers a new option for the treatment of bone metastases from prostate cancer. As cancer treatment progresses towards personalization, the potential for an individualized approach is exemplified in treatments with radiotherapeutics due to the unique ability to image in vivo the uptake and retention of the therapeutic agent. This is unmatched in any other field of medicine. Currently, <sup>223</sup>Ra is administered according to standard fixed administrations, modified according to patient weight. Although gamma emissions comprise only 1% of the total emitted energy, there are increasing reports that quantitative imaging is feasible and can facilitate patient-specific dosimetry. The aim of this article is to review the application of imaging and dosimetry for <sup>223</sup>Ra and to consider the potential for treatment optimization accordingly, in order to ensure clinical and cost effectiveness of this promising agent.
Collections
Licenseref URL
https://creativecommons.org/licenses/by-nc/4.0Version of record
Subject
Humans
Bone Neoplasms
Prostatic Neoplasms
Radium
Radioisotopes
Radiometry
Male
Precision Medicine
Research team
Radioisotope Physics
Language
eng
License start date
2017-08
Citation
The British journal of radiology, 2017, 90 (1077), pp. 20160748 - ?