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dc.contributor.authorFlux, GDen_US
dc.coverage.spatialEnglanden_US
dc.date.accessioned2018-02-19T12:43:08Z
dc.date.issued2017-08en_US
dc.identifierhttps://www.ncbi.nlm.nih.gov/pubmed/28654303en_US
dc.identifier.citationBr J Radiol, 2017, 90 (1077), pp. 20160748 - ?en_US
dc.identifier.urihttps://repository.icr.ac.uk/handle/internal/1297
dc.identifier.eissn1748-880Xen_US
dc.identifier.doi10.1259/bjr.20160748en_US
dc.description.abstractRadium-223 (223Ra) offers a new option for the treatment of bone metastases from prostate cancer. As cancer treatment progresses towards personalization, the potential for an individualized approach is exemplified in treatments with radiotherapeutics due to the unique ability to image in vivo the uptake and retention of the therapeutic agent. This is unmatched in any other field of medicine. Currently, 223Ra is administered according to standard fixed administrations, modified according to patient weight. Although gamma emissions comprise only 1% of the total emitted energy, there are increasing reports that quantitative imaging is feasible and can facilitate patient-specific dosimetry. The aim of this article is to review the application of imaging and dosimetry for 223Ra and to consider the potential for treatment optimization accordingly, in order to ensure clinical and cost effectiveness of this promising agent.en_US
dc.format.extent20160748 - ?en_US
dc.languageengen_US
dc.language.isoengen_US
dc.subjectBone Neoplasmsen_US
dc.subjectHumansen_US
dc.subjectMaleen_US
dc.subjectPrecision Medicineen_US
dc.subjectProstatic Neoplasmsen_US
dc.subjectRadioisotopesen_US
dc.subjectRadiometryen_US
dc.subjectRadiumen_US
dc.titleImaging and dosimetry for radium-223: the potential for personalized treatment.en_US
dc.typeJournal Article
rioxxterms.versionofrecord10.1259/bjr.20160748en_US
rioxxterms.licenseref.startdate2017-08en_US
rioxxterms.typeJournal Article/Reviewen_US
dc.relation.isPartOfBr J Radiolen_US
pubs.issue1077en_US
pubs.notesNot knownen_US
pubs.organisational-group/ICR
pubs.organisational-group/ICR/Primary Group
pubs.organisational-group/ICR/Primary Group/ICR Divisions
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Radiotherapy and Imaging
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Radiotherapy and Imaging/Radioisotope Physics
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Radiotherapy and Imaging/Radioisotope Physics/Radioisotope Physics (hon.)
pubs.organisational-group/ICR/Primary Group/Royal Marsden Clinical Units
pubs.publication-statusPublisheden_US
pubs.volume90en_US
pubs.embargo.termsNot knownen_US
icr.researchteamRadioisotope Physicsen_US
dc.contributor.icrauthorFlux, Glennen_US
dc.contributor.icrauthorMarsden,en_US


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