Show simple item record

dc.contributor.authorBurton, A
dc.contributor.authorMaskarinec, G
dc.contributor.authorPerez-Gomez, B
dc.contributor.authorVachon, C
dc.contributor.authorMiao, H
dc.contributor.authorLajous, M
dc.contributor.authorLópez-Ridaura, R
dc.contributor.authorRice, M
dc.contributor.authorPereira, A
dc.contributor.authorGarmendia, ML
dc.contributor.authorTamimi, RM
dc.contributor.authorBertrand, K
dc.contributor.authorKwong, A
dc.contributor.authorUrsin, G
dc.contributor.authorLee, E
dc.contributor.authorQureshi, SA
dc.contributor.authorMa, H
dc.contributor.authorVinnicombe, S
dc.contributor.authorMoss, S
dc.contributor.authorAllen, S
dc.contributor.authorNdumia, R
dc.contributor.authorVinayak, S
dc.contributor.authorTeo, S-H
dc.contributor.authorMariapun, S
dc.contributor.authorFadzli, F
dc.contributor.authorPeplonska, B
dc.contributor.authorBukowska, A
dc.contributor.authorNagata, C
dc.contributor.authorStone, J
dc.contributor.authorHopper, J
dc.contributor.authorGiles, G
dc.contributor.authorOzmen, V
dc.contributor.authorAribal, ME
dc.contributor.authorSchüz, J
dc.contributor.authorVan Gils, CH
dc.contributor.authorWanders, JOP
dc.contributor.authorSirous, R
dc.contributor.authorSirous, M
dc.contributor.authorHipwell, J
dc.contributor.authorKim, J
dc.contributor.authorLee, JW
dc.contributor.authorDickens, C
dc.contributor.authorHartman, M
dc.contributor.authorChia, K-S
dc.contributor.authorScott, C
dc.contributor.authorChiarelli, AM
dc.contributor.authorLinton, L
dc.contributor.authorPollan, M
dc.contributor.authorFlugelman, AA
dc.contributor.authorSalem, D
dc.contributor.authorKamal, R
dc.contributor.authorBoyd, N
dc.contributor.authorDos-Santos-Silva, I
dc.contributor.authorMcCormack, V
dc.date.accessioned2018-02-19T12:43:51Z
dc.date.issued2017-06-30
dc.identifier.citationPLoS medicine, 2017, 14 (6), pp. e1002335 - ?
dc.identifier.issn1549-1277
dc.identifier.urihttps://repository.icr.ac.uk/handle/internal/1299
dc.identifier.eissn1549-1676
dc.identifier.doi10.1371/journal.pmed.1002335
dc.description.abstractBackground Mammographic density (MD) is one of the strongest breast cancer risk factors. Its age-related characteristics have been studied in women in western countries, but whether these associations apply to women worldwide is not known.Methods and findings We examined cross-sectional differences in MD by age and menopausal status in over 11,000 breast-cancer-free women aged 35-85 years, from 40 ethnicity- and location-specific population groups across 22 countries in the International Consortium on Mammographic Density (ICMD). MD was read centrally using a quantitative method (Cumulus) and its square-root metrics were analysed using meta-analysis of group-level estimates and linear regression models of pooled data, adjusted for body mass index, reproductive factors, mammogram view, image type, and reader. In all, 4,534 women were premenopausal, and 6,481 postmenopausal, at the time of mammography. A large age-adjusted difference in percent MD (PD) between post- and premenopausal women was apparent (-0.46 cm [95% CI: -0.53, -0.39]) and appeared greater in women with lower breast cancer risk profiles; variation across population groups due to heterogeneity (I2) was 16.5%. Among premenopausal women, the √PD difference per 10-year increase in age was -0.24 cm (95% CI: -0.34, -0.14; I2 = 30%), reflecting a compositional change (lower dense area and higher non-dense area, with no difference in breast area). In postmenopausal women, the corresponding difference in √PD (-0.38 cm [95% CI: -0.44, -0.33]; I2 = 30%) was additionally driven by increasing breast area. The study is limited by different mammography systems and its cross-sectional rather than longitudinal nature.Conclusions Declines in MD with increasing age are present premenopausally, continue postmenopausally, and are most pronounced over the menopausal transition. These effects were highly consistent across diverse groups of women worldwide, suggesting that they result from an intrinsic biological, likely hormonal, mechanism common to women. If cumulative breast density is a key determinant of breast cancer risk, younger ages may be the more critical periods for lifestyle modifications aimed at breast density and breast cancer risk reduction.
dc.formatElectronic-eCollection
dc.format.extente1002335 - ?
dc.languageeng
dc.language.isoeng
dc.rights.urihttps://creativecommons.org/licenses/by/4.0
dc.subjectHumans
dc.subjectCross-Sectional Studies
dc.subjectAging
dc.subjectPerimenopause
dc.subjectPostmenopause
dc.subjectPremenopause
dc.subjectAdult
dc.subjectAged
dc.subjectAged, 80 and over
dc.subjectMiddle Aged
dc.subjectFemale
dc.subjectBreast Density
dc.titleMammographic density and ageing: A collaborative pooled analysis of cross-sectional data from 22 countries worldwide.
dc.typeJournal Article
dcterms.dateAccepted2017-05-24
rioxxterms.versionofrecord10.1371/journal.pmed.1002335
rioxxterms.licenseref.urihttps://creativecommons.org/licenses/by/4.0
rioxxterms.licenseref.startdate2017-06-30
rioxxterms.typeJournal Article/Review
dc.relation.isPartOfPLoS medicine
pubs.issue6
pubs.notesNot known
pubs.organisational-group/ICR
pubs.organisational-group/ICR/Primary Group
pubs.organisational-group/ICR/Primary Group/Royal Marsden Clinical Units
pubs.organisational-group/ICR
pubs.organisational-group/ICR/Primary Group
pubs.organisational-group/ICR/Primary Group/Royal Marsden Clinical Units
pubs.publication-statusPublished
pubs.volume14
pubs.embargo.termsNot known
dc.contributor.icrauthorMarsden,en


Files in this item

Thumbnail

This item appears in the following collection(s)

Show simple item record

https://creativecommons.org/licenses/by/4.0
Except where otherwise noted, this item's license is described as https://creativecommons.org/licenses/by/4.0