Nintedanib plus docetaxel as second-line therapy in patients with non-small-cell lung cancer of adenocarcinoma histology: a network meta-analysis vs new therapeutic options.

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Date
2017-06Author
Popat, S
Mellemgaard, A
Reck, M
Hastedt, C
Griebsch, I
Type
Journal Article
Metadata
Show full item recordAbstract
Patients & methods We provide an update to a network meta-analysis evaluating the relative efficacy of nintedanib + docetaxel versus other second-line agents in adenocarcinoma histology non-small-cell lung cancer.Results Overall similarity of nintedanib + docetaxel versus ramucirumab + docetaxel, and versus nivolumab. Comparing nintedanib + docetaxel with nivolumab, hazards ratio (HR) of overall survival and progression-free survival (PFS) pointed in opposite directions (overall survival: HR: 1.20 [95% credible interval: 0.92-1.58]; PFS: HR: 0.91 [0.68-1.21]). Exploratory subgroup analysis indicated superiority of nivolumab in high PD-L1 expression level subgroups; results were more favorable for nintedanib in all subgroups with low (<1%, <5%, <10%) PD-L1 expression levels - in particular, with regard to PFS.Conclusion Results demonstrated similar efficacy of nintedanib + docetaxel compared with the new therapeutic options ramucirumab + docetaxel and nivolumab, with potential differences in subgroups according to PD-L1 expression level.
Collections
Subject
Humans
Adenocarcinoma
Carcinoma, Non-Small-Cell Lung
Taxoids
Indoles
Antineoplastic Combined Chemotherapy Protocols
Antibodies, Monoclonal
Disease-Free Survival
Treatment Outcome
Gene Expression Regulation, Neoplastic
Antibodies, Monoclonal, Humanized
Network Meta-Analysis
B7-H1 Antigen
Docetaxel
Nivolumab
Research team
Thoracic Oncology
Language
eng
License start date
2017-06
Citation
Future oncology (London, England), 2017, 13 (13), pp. 1159 - 1171