Olaratumab for the treatment of soft-tissue sarcoma.
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The outcome for patients with unresectable/metastatic soft tissue sarcoma remains poor with few treatment options. In the first line setting, a number of randomized trials have shown no difference in overall survival between combination anthracycline schedules and single agent doxorubicin. A Phase Ib/randomized Phase II trial of doxorubicin with or without the monoclonal antibody to PDGFR-α, olaratumab, demonstrated a significant difference in median overall survival in favor of the olaratumab arm. The results of this trial led to approval of olaratumab in combination with doxorubicin in adult anthracycline-naive unresectable soft tissue sarcoma. In this review, we describe some of the preclinical and early clinical data of olaratumab in sarcomas, the Phase Ib/II trial and ongoing trials with olaratumab in sarcomas.
Drug Evaluation, Preclinical
Clinical Trials as Topic
Molecular Targeted Therapy
Antineoplastic Agents, Immunological
Sarcoma Clinical Trials (R Jones)
Lung Cancer Group
License start date
Future oncology (London, England), 2017, 13 (24), pp. 2151 - 2157
FUTURE MEDICINE LTD