Clinical benefit of antiangiogenic therapy in advanced and metastatic chondrosarcoma.
Abstract
Chondrosarcoma is the most common bone sarcoma in adults. Conventional chondrosarcoma, the commonest histological subtype, is largely resistant to anthracycline-based chemotherapy. There have been anecdotal reports of durable clinical benefit with antiangiogenic agents in this disease. A retrospective search of patients treated at three sarcoma referral centers was performed to identify patients with advanced chondrosarcoma treated with antiangiogenic agents. The aim of this study was to evaluate the efficacy and safety of antiangiogenic agents in advanced chondrosarcoma. Ten patients were identified; seven with conventional, one each with clear cell, extraskeletal mesenchymal chondrosarcoma and extraskeletal myxoid chondrosarcoma. The median progression-free survival for patients with conventional and clear cell sarcoma was 22.6 months. Median overall survival has not been met. Antiangiogenic therapy was well tolerated in this series of patients. Our retrospective data suggest that antiangiogenic therapy can provide prolonged clinical benefit in advanced chondrosarcoma patients. Further prospective trials are required to precisely define the role of this class of agent in advanced chondrosarcoma.
Collections
Subject
Humans
Neoplasms, Connective and Soft Tissue
Chondrosarcoma
Bone Neoplasms
Lung Neoplasms
Sulfonamides
Pyrimidines
Angiogenesis Inhibitors
Antineoplastic Combined Chemotherapy Protocols
Antibodies, Monoclonal
Disease-Free Survival
Treatment Outcome
Retrospective Studies
Adult
Aged
Middle Aged
Female
Male
Antibodies, Monoclonal, Humanized
Research team
Sarcoma Clinical Trials (R Jones)
Language
eng
Date accepted
2017-08-22
License start date
2017-08-29
Citation
Medical oncology (Northwood, London, England), 2017, 34 (10), pp. 167 - ?