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dc.contributor.authorEaton, DJ
dc.contributor.authorTyler, J
dc.contributor.authorBackshall, A
dc.contributor.authorBernstein, D
dc.contributor.authorCarver, A
dc.contributor.authorGasnier, A
dc.contributor.authorHenderson, J
dc.contributor.authorLee, J
dc.contributor.authorPatel, R
dc.contributor.authorTsang, Y
dc.contributor.authorYang, H
dc.contributor.authorZotova, R
dc.contributor.authorWells, E
dc.date.accessioned2018-02-20T12:07:19Z
dc.date.issued2017-03
dc.identifier.citationPhysica medica : PM : an international journal devoted to the applications of physics to medicine and biology : official journal of the Italian Association of Biomedical Physics (AIFB), 2017, 35 pp. 25 - 30
dc.identifier.issn1120-1797
dc.identifier.urihttps://repository.icr.ac.uk/handle/internal/1404
dc.identifier.eissn1724-191X
dc.identifier.doi10.1016/j.ejmp.2017.02.012
dc.description.abstractPurpose External dosimetry audits give confidence in the safe and accurate delivery of radiotherapy. The RTTQA group have performed an on-site audit programme for trial recruiting centres, who have recently implemented static or rotational IMRT, and those with major changes to planning or delivery systems.Methods Measurements of reference beam output were performed by the host centre, and by the auditor using independent equipment. Verification of clinical plans was performed using the ArcCheck helical diode array.Results A total of 54 measurement sessions were performed between May 2014 and June 2016 at 28 UK institutions, reflecting the different combinations of planning and delivery systems used at each institution. Average ratio of measured output between auditor and host was 1.002±0.006. Average point dose agreement for clinical plans was -0.3±1.8%. Average (and 95% lower confidence intervals) of gamma pass rates at 2%/2mm, 3%/2mm and 3%/3mm respectively were: 92% (80%), 96% (90%) and 98% (94%). Moderately significant differences were seen between fixed gantry angle and rotational IMRT, and between combination of planning systems and linac manufacturer, but not between anatomical treatment site or beam energy.Conclusion An external audit programme has been implemented for universal and efficient credentialing of IMRT treatments in clinical trials. Good agreement was found between measured and expected doses, with few outliers, leading to a simple table of optimal and mandatory tolerances for approval of dosimetry audit results. Feedback was given to some centres leading to improved clinical practice.
dc.formatPrint-Electronic
dc.format.extent25 - 30
dc.languageeng
dc.language.isoeng
dc.subjectRadiotherapy Dosage
dc.subjectRadiotherapy Planning, Computer-Assisted
dc.subjectRadiometry
dc.subjectCredentialing
dc.subjectQuality Assurance, Health Care
dc.subjectRadiotherapy, Intensity-Modulated
dc.subjectClinical Trials as Topic
dc.subjectUnited Kingdom
dc.titleAn external dosimetry audit programme to credential static and rotational IMRT delivery for clinical trials quality assurance.
dc.typeJournal Article
dcterms.dateAccepted2017-02-14
rioxxterms.versionofrecord10.1016/j.ejmp.2017.02.012
rioxxterms.licenseref.startdate2017-03
rioxxterms.typeJournal Article/Review
dc.relation.isPartOfPhysica medica : PM : an international journal devoted to the applications of physics to medicine and biology : official journal of the Italian Association of Biomedical Physics (AIFB)
pubs.notesNot known
pubs.organisational-group/ICR
pubs.organisational-group/ICR/Primary Group
pubs.organisational-group/ICR/Primary Group/ICR Divisions
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Radiotherapy and Imaging
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Radiotherapy and Imaging/Radiotherapy Physics Modelling
pubs.organisational-group/ICR/Primary Group/Royal Marsden Clinical Units
pubs.organisational-group/ICR
pubs.organisational-group/ICR/Primary Group
pubs.organisational-group/ICR/Primary Group/ICR Divisions
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Radiotherapy and Imaging
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Radiotherapy and Imaging/Radiotherapy Physics Modelling
pubs.organisational-group/ICR/Primary Group/Royal Marsden Clinical Units
pubs.publication-statusPublished
pubs.volume35
pubs.embargo.termsNot known
icr.researchteamRadiotherapy Physics Modellingen_US
dc.contributor.icrauthorMarsden,en
dc.contributor.icrauthorBernstein, Daviden


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