Show simple item record

dc.contributor.authorCheng, CL
dc.contributor.authorO'Connor, S
dc.date.accessioned2018-03-05T12:48:32Z
dc.date.issued2017-03
dc.identifier.citationJournal of clinical pathology, 2017, 70 (3), pp. 187 - 201
dc.identifier.issn0021-9746
dc.identifier.urihttps://repository.icr.ac.uk/handle/internal/1535
dc.identifier.eissn1472-4146
dc.identifier.doi10.1136/jclinpath-2016-204065
dc.description.abstractAccurate diagnostic interpretation of a lymphoid population composed predominantly of small T cells, together with smaller numbers of large B cells, with or without a nodular architecture, is a common problem faced by the histopathologist. The differential diagnosis of this histological pattern is wide, ranging from reactive conditions such as drug reactions and viral infections, through borderline entities such as immunodeficiency-related lymphoproliferative disorders to lymphomas. The latter includes entities where the large B cells are primarily neoplastic (classical and nodular lymphocyte-predominant Hodgkin lymphomas and T cell/histiocyte-rich large B cell lymphoma) as well as T cell lymphomas such as angioimmunoblastic T cell lymphoma where the large B cells represent an epiphenomenon and may or may not be neoplastic. Several rare variants of these conditions, and the fact that treatment can significantly modify appearances, add to the diagnostic difficulty of these pathological entities. Unlike monomorphic lymphoid infiltrates, the histological pattern of T cell-rich proliferation with large B cells requires close evaluation of the inter-relationship between B cells and T cells, follicular dendritic cells and sometimes other inflammatory cells. Epstein-Barr virus plays a key role in several of these scenarios, and interpreting not only its presence but also its distribution within cellular subgroups is essential to accurate diagnosis and the avoidance of some important diagnostic pitfalls. An understanding of normal immunoarchitecture and lymphoid maturational pathways is also fundamental to resolving these cases, as is a knowledge of their common patterns of spread, which facilitates correlation with clinical and radiological findings.
dc.formatPrint-Electronic
dc.format.extent187 - 201
dc.languageeng
dc.language.isoeng
dc.subjectLymph Nodes
dc.subjectB-Lymphocytes
dc.subjectT-Lymphocytes
dc.subjectHumans
dc.subjectLymphoproliferative Disorders
dc.subjectDiagnosis, Differential
dc.titleT cell-rich lymphoid infiltrates with large B cells: a review of key entities and diagnostic approach.
dc.typeJournal Article
dcterms.dateAccepted2016-11-01
rioxxterms.versionofrecord10.1136/jclinpath-2016-204065
rioxxterms.licenseref.startdate2017-03
rioxxterms.typeJournal Article/Review
dc.relation.isPartOfJournal of clinical pathology
pubs.issue3
pubs.notesNot known
pubs.organisational-group/ICR
pubs.organisational-group/ICR/Primary Group
pubs.organisational-group/ICR/Primary Group/Royal Marsden Clinical Units
pubs.organisational-group/ICR
pubs.organisational-group/ICR/Primary Group
pubs.organisational-group/ICR/Primary Group/Royal Marsden Clinical Units
pubs.publication-statusPublished
pubs.volume70
pubs.embargo.termsNot known
dc.contributor.icrauthorMarsden,en


Files in this item

Thumbnail

This item appears in the following collection(s)

Show simple item record