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dc.contributor.authorShi, J
dc.contributor.authorZhang, Y
dc.contributor.authorZheng, W
dc.contributor.authorMichailidou, K
dc.contributor.authorGhoussaini, M
dc.contributor.authorBolla, MK
dc.contributor.authorWang, Q
dc.contributor.authorDennis, J
dc.contributor.authorLush, M
dc.contributor.authorMilne, RL
dc.contributor.authorShu, X-O
dc.contributor.authorBeesley, J
dc.contributor.authorKar, S
dc.contributor.authorAndrulis, IL
dc.contributor.authorAnton-Culver, H
dc.contributor.authorArndt, V
dc.contributor.authorBeckmann, MW
dc.contributor.authorZhao, Z
dc.contributor.authorGuo, X
dc.contributor.authorBenitez, J
dc.contributor.authorBeeghly-Fadiel, A
dc.contributor.authorBlot, W
dc.contributor.authorBogdanova, NV
dc.contributor.authorBojesen, SE
dc.contributor.authorBrauch, H
dc.contributor.authorBrenner, H
dc.contributor.authorBrinton, L
dc.contributor.authorBroeks, A
dc.contributor.authorBrüning, T
dc.contributor.authorBurwinkel, B
dc.contributor.authorCai, H
dc.contributor.authorCanisius, S
dc.contributor.authorChang-Claude, J
dc.contributor.authorChoi, J-Y
dc.contributor.authorCouch, FJ
dc.contributor.authorCox, A
dc.contributor.authorCross, SS
dc.contributor.authorCzene, K
dc.contributor.authorDarabi, H
dc.contributor.authorDevilee, P
dc.contributor.authorDroit, A
dc.contributor.authorDork, T
dc.contributor.authorFasching, PA
dc.contributor.authorFletcher, O
dc.contributor.authorFlyger, H
dc.contributor.authorFostira, F
dc.contributor.authorGaborieau, V
dc.contributor.authorGarcía-Closas, M
dc.contributor.authorGiles, GG
dc.contributor.authorMervi Grip
dc.contributor.authorGuenel, P
dc.contributor.authorHaiman, CA
dc.contributor.authorHamann, U
dc.contributor.authorHartman, M
dc.contributor.authorMiao, H
dc.contributor.authorHollestelle, A
dc.contributor.authorHopper, JL
dc.contributor.authorHsiung, C-N
dc.contributor.authorkConFab Investigators
dc.contributor.authorIto, H
dc.contributor.authorJakubowska, A
dc.contributor.authorJohnson, N
dc.contributor.authorTorres, D
dc.contributor.authorKabisch, M
dc.contributor.authorKang, D
dc.contributor.authorKhan, S
dc.contributor.authorKnight, JA
dc.contributor.authorKosma, V-M
dc.contributor.authorLambrechts, D
dc.contributor.authorLi, J
dc.contributor.authorLindblom, A
dc.contributor.authorLophatananon, A
dc.contributor.authorLubinski, J
dc.contributor.authorMannermaa, A
dc.contributor.authorManoukian, S
dc.contributor.authorLe Marchand, L
dc.contributor.authorMargolin, S
dc.contributor.authorMarme, F
dc.contributor.authorMatsuo, K
dc.contributor.authorMcLean, C
dc.contributor.authorMeindl, A
dc.contributor.authorMuir, K
dc.contributor.authorNeuhausen, SL
dc.contributor.authorNevanlinna, H
dc.contributor.authorNord, S
dc.contributor.authorBørresen-Dale, A-L
dc.contributor.authorOlson, JE
dc.contributor.authorOrr, N
dc.contributor.authorvan den Ouweland, AMW
dc.contributor.authorPeterlongo, P
dc.contributor.authorPutti, TC
dc.contributor.authorRudolph, A
dc.contributor.authorSangrajrang, S
dc.contributor.authorSawyer, EJ
dc.contributor.authorSchmidt, MK
dc.contributor.authorSchmutzler, RK
dc.contributor.authorShen, C-Y
dc.contributor.authorHou, M-F
dc.contributor.authorShrubsole, MJ
dc.contributor.authorSouthey, MC
dc.contributor.authorSwerdlow, A
dc.contributor.authorTeo, SH
dc.contributor.authorThienpont, B
dc.contributor.authorToland, AE
dc.contributor.authorTollenaar, RAEM
dc.contributor.authorTomlinson, I
dc.contributor.authorTruong, T
dc.contributor.authorTseng, C-C
dc.contributor.authorWen, W
dc.contributor.authorWinqvist, R
dc.contributor.authorWu, AH
dc.contributor.authorYip, CH
dc.contributor.authorZamora, PM
dc.contributor.authorZheng, Y
dc.contributor.authorFloris, G
dc.contributor.authorCheng, C-Y
dc.contributor.authorHooning, MJ
dc.contributor.authorMartens, JWM
dc.contributor.authorSeynaeve, C
dc.contributor.authorKristensen, VN
dc.contributor.authorHall, P
dc.contributor.authorPharoah, PDP
dc.contributor.authorSimard, J
dc.contributor.authorChenevix-Trench, G
dc.contributor.authorDunning, AM
dc.contributor.authorAntoniou, AC
dc.contributor.authorEaston, DF
dc.contributor.authorCai, Q
dc.contributor.authorLong, J
dc.date.accessioned2016-10-03T12:18:17Z
dc.date.issued2016-09
dc.identifier.citationInternational journal of cancer, 2016, 139 (6), pp. 1303 - 1317
dc.identifier.issn0020-7136
dc.identifier.urihttps://repository.icr.ac.uk/handle/internal/159
dc.identifier.eissn1097-0215
dc.identifier.doi10.1002/ijc.30150
dc.description.abstractPrevious genome-wide association studies among women of European ancestry identified two independent breast cancer susceptibility loci represented by single nucleotide polymorphisms (SNPs) rs13281615 and rs11780156 at 8q24. A fine-mapping study across 2.06 Mb (chr8:127,561,724-129,624,067, hg19) in 55,540 breast cancer cases and 51,168 controls within the Breast Cancer Association Consortium was conducted. Three additional independent association signals in women of European ancestry, represented by rs35961416 (OR = 0.95, 95% CI = 0.93-0.97, conditional p = 5.8 × 10(-6) ), rs7815245 (OR = 0.94, 95% CI = 0.91-0.96, conditional p = 1.1 × 10(-6) ) and rs2033101 (OR = 1.05, 95% CI = 1.02-1.07, conditional p = 1.1 × 10(-4) ) were found. Integrative analysis using functional genomic data from the Roadmap Epigenomics, the Encyclopedia of DNA Elements project, the Cancer Genome Atlas and other public resources implied that SNPs rs7815245 in Signal 3, and rs1121948 in Signal 5 (in linkage disequilibrium with rs11780156, r(2)  = 0.77), were putatively functional variants for two of the five independent association signals. The results highlighted multiple 8q24 variants associated with breast cancer susceptibility in women of European ancestry.
dc.formatPrint-Electronic
dc.format.extent1303 - 1317
dc.languageeng
dc.language.isoeng
dc.subjectMervi Grip
dc.subjectkConFab Investigators
dc.subjectChromosomes, Human, Pair 8
dc.subjectHumans
dc.subjectBreast Neoplasms
dc.subjectOdds Ratio
dc.subjectRisk
dc.subjectCase-Control Studies
dc.subjectChromosome Mapping
dc.subjectGenotype
dc.subjectHaplotypes
dc.subjectLinkage Disequilibrium
dc.subjectPolymorphism, Single Nucleotide
dc.subjectAlleles
dc.subjectQuantitative Trait Loci
dc.subjectEuropean Continental Ancestry Group
dc.subjectFemale
dc.subjectGenetic Variation
dc.subjectGenome-Wide Association Study
dc.titleFine-scale mapping of 8q24 locus identifies multiple independent risk variants for breast cancer.
dc.typeJournal Article
dcterms.dateAccepted2016-01-19
rioxxterms.versionofrecord10.1002/ijc.30150
rioxxterms.licenseref.startdate2016-09
rioxxterms.typeJournal Article/Review
dc.relation.isPartOfInternational journal of cancer
pubs.issue6
pubs.notes12 months
pubs.organisational-group/ICR
pubs.organisational-group/ICR/Primary Group
pubs.organisational-group/ICR/Primary Group/ICR Divisions
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Breast Cancer Research
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Breast Cancer Research/Aetiological Epidemiology
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Breast Cancer Research/Complex Trait Genetics
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Breast Cancer Research/Functional Genetic Epidemiology
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Genetics and Epidemiology
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Genetics and Epidemiology/Aetiological Epidemiology
pubs.organisational-group/ICR
pubs.organisational-group/ICR/Primary Group
pubs.organisational-group/ICR/Primary Group/ICR Divisions
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Breast Cancer Research
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Breast Cancer Research/Aetiological Epidemiology
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Breast Cancer Research/Complex Trait Genetics
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Breast Cancer Research/Functional Genetic Epidemiology
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Genetics and Epidemiology
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Genetics and Epidemiology/Aetiological Epidemiology
pubs.publication-statusPublished
pubs.volume139
pubs.embargo.terms12 months
icr.researchteamComplex Trait Geneticsen_US
icr.researchteamFunctional Genetic Epidemiologyen_US
icr.researchteamAetiological Epidemiologyen_US
dc.contributor.icrauthorFletcher, Oliviaen
dc.contributor.icrauthorSwerdlow, Anthonyen
dc.contributor.icrauthorOrr, Nicholasen


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