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dc.contributor.authorLoveday, Cen_US
dc.contributor.authorLitchfield, Ken_US
dc.contributor.authorLevy, Men_US
dc.contributor.authorHolroyd, Aen_US
dc.contributor.authorBroderick, Pen_US
dc.contributor.authorKote-Jarai, Zen_US
dc.contributor.authorDunning, AMen_US
dc.contributor.authorMuir, Ken_US
dc.contributor.authorPeto, Jen_US
dc.contributor.authorEeles, Ren_US
dc.contributor.authorEaston, DFen_US
dc.contributor.authorDudakia, Den_US
dc.contributor.authorOrr, Nen_US
dc.contributor.authorPashayan, Nen_US
dc.contributor.authorReid, Aen_US
dc.contributor.authorHuddart, RAen_US
dc.contributor.authorHoulston, RSen_US
dc.contributor.authorTurnbull, Cen_US
dc.date.accessioned2018-03-28T14:46:15Z
dc.date.issued2018-02en_US
dc.identifier.citationOncotarget, 2018, 9 (16), pp. 12630 - 12638en_US
dc.identifier.issn1949-2553en_US
dc.identifier.urihttps://repository.icr.ac.uk/handle/internal/1621
dc.identifier.eissn1949-2553en_US
dc.identifier.doi10.18632/oncotarget.23117en_US
dc.description.abstractTesticular germ cell tumor (TGCT), the most common cancer in men aged 18 to 45 years, has a strong heritable basis. Genome-wide association studies (GWAS) have proposed single nucleotide polymorphisms (SNPs) at a number of loci influencing TGCT risk. To further evaluate the association of recently proposed risk SNPs with TGCT at 2q14.2, 3q26.2, 7q36.3, 10q26.13 and 15q21.3, we analyzed genotype data on 3,206 cases and 7,422 controls. Our analysis provides independent replication of the associations for risk SNPs at 2q14.2 (rs2713206 at P = 3.03 × 10-2; P-meta = 3.92 × 10-8; nearest gene, TFCP2L1) and rs12912292 at 15q21.3 (P = 7.96 × 10-11; P-meta = 1.55 × 10-19; nearest gene PRTG). Case-only analyses did not reveal specific associations with TGCT histology. TFCP2L1 joins the growing list of genes located within TGCT risk loci with biologically plausible roles in developmental transcriptional regulation, further highlighting the importance of this phenomenon in TGCT oncogenesis.en_US
dc.formatElectronic-eCollectionen_US
dc.format.extent12630 - 12638en_US
dc.languageengen_US
dc.language.isoengen_US
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/en_US
dc.titleValidation of loci at 2q14.2 and 15q21.3 as risk factors for testicular cancer.en_US
dc.typeJournal Article
dcterms.dateAccepted2017-11-15en_US
rioxxterms.versionofrecord10.18632/oncotarget.23117en_US
rioxxterms.licenseref.urihttps://creativecommons.org/licenses/by/4.0en_US
rioxxterms.licenseref.startdate2018-02en_US
rioxxterms.typeJournal Article/Reviewen_US
dc.relation.isPartOfOncotargeten_US
pubs.issue16en_US
pubs.notesNot knownen_US
pubs.organisational-group/ICR
pubs.organisational-group/ICR/Primary Group
pubs.organisational-group/ICR/Primary Group/ICR Divisions
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Breast Cancer Research
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Breast Cancer Research/Complex Trait Genetics
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Genetics and Epidemiology
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Genetics and Epidemiology/Cancer Genomics
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Genetics and Epidemiology/Oncogenetics
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Molecular Pathology
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Molecular Pathology/Molecular & Population Genetics
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Radiotherapy and Imaging
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Radiotherapy and Imaging/Clinical Academic Radiotherapy (Huddart)
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Radiotherapy and Imaging/Oncogenetics
pubs.publication-statusPublisheden_US
pubs.volume9en_US
pubs.embargo.termsNot knownen_US
icr.researchteamComplex Trait Geneticsen_US
icr.researchteamCancer Genomicsen_US
icr.researchteamMolecular & Population Geneticsen_US
icr.researchteamClinical Academic Radiotherapy (Huddart)en_US
icr.researchteamOncogeneticsen_US
dc.contributor.icrauthorHuddart, Roberten_US
dc.contributor.icrauthorOrr, Nicholasen_US
dc.contributor.icrauthorBroderick, Peteren_US
dc.contributor.icrauthorHoulston, Richarden_US
dc.contributor.icrauthorEeles, Rosalinden_US
dc.contributor.icrauthorKote-Jarai, Zsofiaen_US
dc.contributor.icrauthorTurnbull, Clareen_US
dc.contributor.icrauthorLitchfield, Kevinen_US


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Except where otherwise noted, this item's license is described as http://creativecommons.org/licenses/by/4.0/