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dc.contributor.authorWalker-Samuel, S
dc.contributor.authorRoberts, TA
dc.contributor.authorRamasawmy, R
dc.contributor.authorBurrell, JS
dc.contributor.authorJohnson, SP
dc.contributor.authorSiow, BM
dc.contributor.authorRichardson, S
dc.contributor.authorGonçalves, MR
dc.contributor.authorPendse, D
dc.contributor.authorRobinson, SP
dc.contributor.authorPedley, RB
dc.contributor.authorLythgoe, MF
dc.date.accessioned2018-04-27T09:53:20Z
dc.date.issued2018-04
dc.identifier.citationCancer research, 2018, 78 (7), pp. 1859 - 1872
dc.identifier.issn0008-5472
dc.identifier.urihttps://repository.icr.ac.uk/handle/internal/1656
dc.identifier.eissn1538-7445
dc.identifier.doi10.1158/0008-5472.can-17-1546
dc.description.abstractSeveral distinct fluid flow phenomena occur in solid tumors, including intravascular blood flow and interstitial convection. Interstitial fluid pressure is often raised in solid tumors, which can limit drug delivery. To probe low-velocity flow in tumors resulting from raised interstitial fluid pressure, we developed a novel MRI technique named convection-MRI, which uses a phase-contrast acquisition with a dual-inversion vascular nulling preparation to separate intra- and extravascular flow. Here, we report the results of experiments in flow phantoms, numerical simulations, and tumor xenograft models to investigate the technical feasibility of convection-MRI. We observed a significant correlation between estimates of effective fluid pressure from convection-MRI with gold-standard, invasive measurements of interstitial fluid pressure in mouse models of human colorectal carcinoma. Our results show how convection-MRI can provide insights into the growth and responsiveness to vascular-targeting therapy in colorectal cancers.Significance: A noninvasive method for measuring low-velocity fluid flow caused by raised fluid pressure can be used to assess changes caused by therapy. Cancer Res; 78(7); 1859-72. ©2018 AACR.
dc.formatPrint-Electronic
dc.format.extent1859 - 1872
dc.languageeng
dc.language.isoeng
dc.rights.urihttps://www.rioxx.net/licenses/under-embargo-all-rights-reserved
dc.subjectCell Line, Tumor
dc.subjectExtracellular Fluid
dc.subjectAnimals
dc.subjectHumans
dc.subjectMice
dc.subjectMice, Nude
dc.subjectColorectal Neoplasms
dc.subjectNeovascularization, Pathologic
dc.subjectMagnetic Resonance Imaging
dc.subjectDrug Delivery Systems
dc.subjectPhantoms, Imaging
dc.subjectModels, Biological
dc.subjectHydrodynamics
dc.titleInvestigating Low-Velocity Fluid Flow in Tumors with Convection-MRI.
dc.typeJournal Article
dcterms.dateAccepted2018-01-05
rioxxterms.versionofrecord10.1158/0008-5472.can-17-1546
rioxxterms.licenseref.urihttps://www.rioxx.net/licenses/under-embargo-all-rights-reserved
rioxxterms.licenseref.startdate2018-04
rioxxterms.typeJournal Article/Review
dc.relation.isPartOfCancer research
pubs.issue7
pubs.notesNot known
pubs.organisational-group/ICR
pubs.organisational-group/ICR/Primary Group
pubs.organisational-group/ICR/Primary Group/ICR Divisions
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Radiotherapy and Imaging
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Radiotherapy and Imaging/Pre-Clinical MRI
pubs.organisational-group/ICR
pubs.organisational-group/ICR/Primary Group
pubs.organisational-group/ICR/Primary Group/ICR Divisions
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Radiotherapy and Imaging
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Radiotherapy and Imaging/Pre-Clinical MRI
pubs.publication-statusPublished
pubs.volume78
pubs.embargo.termsNot known
icr.researchteamPre-Clinical MRIen_US
dc.contributor.icrauthorRobinson, Simonen


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