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dc.date.accessioned2018-06-04T15:09:15Z
dc.date.issued2016-06
dc.identifierhttp://publications.icr.ac.uk/15172/
dc.identifier.citationBIOCHEMICAL SOCIETY TRANSACTIONS, 2016, 44 pp. 925 - 931
dc.identifier.issn0300-5127
dc.identifier.urihttps://repository.icr.ac.uk/handle/internal/1696
dc.description.abstractAll cancers depend upon mutations in critical genes, which confer a selective advantage to the tumour cell. Knowledge of these mutations is crucial to understanding the biology of cancer initiation and progression, and to the development of targeted therapeutic strategies. The key to understanding the contribution of a disease-associated mutation to the development and progression of cancer, comes from an understanding of the consequences of that mutation on the function of the affected protein, and the impact on the pathways in which that protein is involved. In this paper we examine themutation patterns observed in oncogenes and tumour suppressors, and discuss different approaches that have been developed to identify drivermutations within cancers that contribute to the disease progress. We also discuss the MOKCa database where we have developed an automatic pipeline that structurally and functionally annotates all proteins from the human proteome that are mutated in cancer.
dc.format.extent925 - 931
dc.languageeng
dc.language.isoeng
dc.rights.urihttps://www.rioxx.net/licenses/all-rights-reserved
dc.subjectmutations oncogene tumour suppressor AMINO-ACID SUBSTITUTIONS CANCER GENOME FUNCTIONAL IMPACT SOMATIC MUTATIONS B-RAF GENES PATHOGENICITY VARIANTS DATABASE TRANSFORMATION
dc.titleMutational patterns in oncogenes and tumour suppressors
dc.typeJournal Article
rioxxterms.licenseref.urihttps://www.rioxx.net/licenses/all-rights-reserved
rioxxterms.licenseref.startdate2016-06
rioxxterms.typeJournal Article/Review
dc.relation.isPartOfBIOCHEMICAL SOCIETY TRANSACTIONS
pubs.notesISI Document Delivery No.: DO1EN Times Cited: 0 Cited Reference Count: 50 Baeissa, Hanadi M. Benstead-Hume, Graeme Richardson, Christopher J. Pearl, Frances M. G. Daphne Jackson Fellowship - Medical Research Council; Medical Research Council studentship [MR/N50189X/1]; King Abdulaziz University [KAU1369] This work was supported by the Daphne Jackson Fellowship funded by the Medical Research Council (to F.M.G.P.); Medical Research Council studentship [grant number MR/N50189X/1 (to G.B.-H.)]; and the King Abdulaziz University [grant number KAU1369 (to H.M.B.)]. 0 PORTLAND PRESS LTD LONDON BIOCHEM SOC T 3
pubs.notesNot known
pubs.organisational-group/ICR
pubs.organisational-group/ICR
pubs.volume44
pubs.embargo.termsNot known
dc.contributor.icrauthorRichardson, Christopheren


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