Synthesis of certain 2'-deoxyuridine derivatives containing substituted phenoxy groups attached to C-5'; evaluation as potential dUTP analogues

Abstract

Synthesis of certain 2 '-deoxyuridine derivatives containing substituted phenoxy groups attached to C-5 '; Evaluation as potential dUTP analogues. Derivatives of 2 ' -deoxyuridine in which the 5 ' -OH group is replaced by a 2,3,6-trifluoro-5-hydroxy-4-nitrophenoxy or a 4- carboxy-2,3,6-trifluoro-5-hydroxyphenoxy group have been prepared for evaluation as possible dUTP analogues. They showed a weak ability to displace radiolabelled dUTP from a dUTP- binding antiserum. The corresponding compounds lacking the three fluorine substituents were prepared for comparison.