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Synthesis of certain 2'-deoxyuridine derivatives containing substituted phenoxy groups attached to C-5'; evaluation as potential dUTP analogues.

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Publication Date
2001-09
ICR Author
Marriott, Jonathan
Hardcastle, Anthea
Jarman, Michael
Author
Marriott, JH
Aherne, GW
Hardcastle, A
Jarman, M
Type
Journal Article
Metadata
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Abstract
Derivatives of 2'-deoxyuridine in which the 5'-OH group is replaced by a 2,3,6-trifluoro-5-hydroxy-4-nitrophenoxy or a 4-carboxy-2,3,6-trifluoro-5-hydroxyphenoxy group have been prepared for evaluation as possible dUTP analogues. They showed a weak ability to displace radiolabelled dUTP from a dUTP-binding antiserum. The corresponding compounds lacking the three fluorine substituents were prepared for comparison.
URL
https://repository.icr.ac.uk/handle/internal/1706
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  • Other ICR Research
Version of record
10.1081/ncn-100105905
Subject
Tumor Cells, Cultured
Humans
Pyrophosphatases
Deoxyuridine
Deoxyuracil Nucleotides
Radioimmunoassay
Magnetic Resonance Spectroscopy
Spectrometry, Mass, Electrospray Ionization
Cross Reactions
Language
eng
License start date
2001-09
Citation
Nucleosides, nucleotides & nucleic acids, 2001, 20 (9), pp. 1691 - 1704

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