Publications Repository

Publications Repository

View Item 
  •   Home
  • ICR Divisions
  • Cancer Biology
  • View Item
  • Home
  • ICR Divisions
  • Cancer Biology
  • View Item
JavaScript is disabled for your browser. Some features of this site may not work without it.

Characteristics of response of oral and pharyngeal mucosa in patients receiving chemo-IMRT for head and neck cancer using hypofractionated accelerated radiotherapy.

Thumbnail
Publication Date
2010-10
ICR Author
Harrington, Kevin
Gulliford, Sarah
Nutting, Chris
Bhide, Shreerang
Newbold, Kate
Author
Bhide, SA
Gulliford, S
Fowler, J
Rosenfelder, N
Newbold, K
Harrington, KJ
Nutting, CM
Type
Journal Article
Metadata
Show full item record
Abstract
<h4>Purpose</h4>This study describes the acute response of oral and pharyngeal mucosa to chemo-IMRT schedules using different doses per fraction.<h4>Materials and methods</h4>Patients, treated in prospective trials of concomitant chemo-IMRT with 2.17 Gy, 2.25 Gy and 2.4 Gy per fraction and identical dose of cisplatin, were included in this study. Acute toxicity was recorded prospectively using the CTCAE v2.0. We describe the incidence and prevalence of grade 3 oral mucositis and dysphagia over time and report the influence of overall treatment time (OTT). The association between the lengths of pharyngeal mucosa receiving 50 Gy (L50) and 60 Gy (L60) and grade 3 dysphagia was tested.<h4>Results</h4>The incidence and the peak prevalence of grade 3 dysphagia were significantly higher in patients receiving 2.4 Gy per fraction. The peak prevalence of grade 3 dysphagia was higher and the recovery was slower in patients with lower OTT (median 38 days vs. 42 days) treatment. There was a significant correlation between L50, L60 and grade 3 dysphagia. A L50 and L60 greater than 8 cm resulted in greater than 60% and 70% incidence of grade 3 dysphagia, respectively.<h4>Conclusion</h4>The length of pharyngeal mucosa receiving doses close to the prescription dose correlates with grade 3 dysphagia. It was observed that incidence of grade 3 dysphagia was lower and recovery from it was quicker in patients with greater OTT.
URL
https://repository.icr.ac.uk/handle/internal/1719
Collections
  • Cancer Biology
  • Radiotherapy and Imaging
Version of record
10.1016/j.radonc.2010.08.013
Subject
Pharynx
Mouth Mucosa
Humans
Carcinoma, Squamous Cell
Head and Neck Neoplasms
Deglutition Disorders
Stomatitis
Cisplatin
Fluorouracil
Antineoplastic Combined Chemotherapy Protocols
Radiotherapy Dosage
Prevalence
Prospective Studies
Adult
Aged
Aged, 80 and over
Middle Aged
Female
Male
Radiotherapy, Intensity-Modulated
Dose Fractionation, Radiation
Research team
Radiotherapy Physics Modelling
Targeted Therapy
Language
eng
Date accepted
2010-08-18
License start date
2010-10
Citation
Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology, 2010, 97 (1), pp. 86 - 91

Browse

All of ICR repositoryICR DivisionsIssue dateAuthorsTitlesSubjectsThis collectionIssue dateAuthorsTitlesSubjects

Statistics

Most popular itemsStatistics by countryMost popular authors
  • Login
  • Registered office: The Institute of Cancer Research, 123 Old Brompton Road, London, SW7 3RP
    A Charity, Not for Profit. Company Limited by Guarantee.
    Registered in England No. 534147. VAT Registration No. GB 849 0581 02.