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dc.contributor.authorMavria, G
dc.date.accessioned2018-06-05T14:38:15Z
dc.date.issued2010-03
dc.identifierhttp://publications.icr.ac.uk/9453/
dc.identifier.citationPLOS ONE, 2010, 5 (3)
dc.identifier.issn1932-6203
dc.identifier.urihttps://repository.icr.ac.uk/handle/internal/1721
dc.description.abstractEndothelial cell migration is an essential aspect of tumor angiogenesis. Rac1 activity is needed for cell migration in vitro implying a requirement for this molecule in angiogenesis in vivo. However, a precise role for Rac1 in tumor angiogenesis has never been addressed. Here we show that depletion of endothelial Rac1 expression in adult mice, unexpectedly, has no effect on tumor growth or tumor angiogenesis. In addition, repression of Rac1 expression does not inhibit VEGF-mediated angiogenesis in vivo or ex vivo, nor does it affect chemotactic migratory responses to VEGF in 3-dimensions. In contrast, the requirement for Rac1 in tumor growth and angiogenesis becomes important when endothelial beta 3-integrin levels are reduced or absent: the enhanced tumor growth, tumor angiogenesis and VEGF-mediated responses in beta 3-null mice are all Rac1-dependent. These data indicate that in the presence of alpha v beta 3-integrin Rac1 is not required for tumor angiogenesis.
dc.languageeng
dc.language.isoeng
dc.publisherPUBLIC LIBRARY SCIENCE
dc.subject3-DIMENSIONAL EXTRACELLULAR MATRICES; CAPILLARY LUMEN FORMATION; ADVANCED SOLID TUMORS; GROWTH-FACTOR; PATHOLOGICAL ANGIOGENESIS; CILENGITIDE EMD-121974; VASCULAR DEVELOPMENT; INTEGRIN INHIBITORS; RAC1 ACTIVATION; CRE-RECOMBINASE
dc.titleEndothelial-Rac1 Is Not Required for Tumor Angiogenesis unless alpha v beta 3-Integrin Is Absent
dc.typeJournal Article
rioxxterms.licenseref.startdate2010-03
rioxxterms.typeJournal Article/Review
dc.relation.isPartOfPLOS ONE
pubs.issue3
pubs.notesNot known
pubs.organisational-group/ICR
pubs.organisational-group/ICR/Primary Group
pubs.organisational-group/ICR/Primary Group/ICR Divisions
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Cancer Biology
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Cancer Biology/Oncogene
pubs.organisational-group/ICR
pubs.organisational-group/ICR/Primary Group
pubs.organisational-group/ICR/Primary Group/ICR Divisions
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Cancer Biology
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Cancer Biology/Oncogene
pubs.volume5en_US
pubs.embargo.termsNot known
pubs.oa-locationhttp://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0009766&type=printable
icr.researchteamOncogeneen_US
dc.contributor.icrauthorMavria, Georgiaen


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