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Use of Cancer-Specific Genomic Rearrangements to Quantify Disease Burden in Plasma from Patients with Solid Tumors

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Publication Date
2010-11
ICR Author
Stratton, Michael
Author
Stratton, M
Type
Journal Article
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Abstract
Detection of recurrent somatic rearrangements routinely allows monitoring of residual disease burden in leukemias, but is not used for most solid tumors. However, next-generation sequencing now allows rapid identification of patient-specific rearrangements in solid tumors. We mapped genomic rearrangements in three cancers and showed that PCR assays for rearrangements could detect a single copy of the tumor genome in plasma without false positives. Disease status, drug responsiveness, and incipient relapse could be serially assessed. In future, this strategy could be readily established in diagnostic laboratories, with major impact on monitoring of disease status and personalizing treatment of solid tumors. (C) 2010 Wiley-Liss, Inc.
URL
https://repository.icr.ac.uk/handle/internal/1777
Open access location
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3145117/
Collections
  • Breast Cancer Research
  • Genetics and Epidemiology
Research team
Genetic Susceptibility
License start date
2010-11
Citation
GENES CHROMOSOMES & CANCER, 2010, 49 pp. 1062 - 1069
Publisher
WILEY-LISS

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