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dc.date.accessioned2018-06-11T08:27:37Z
dc.date.issued2013-03
dc.identifier6
dc.identifier.citationINTERNATIONAL JOURNAL OF CANCER, 2013, 132 pp. 1311 - 1322
dc.identifier.urihttps://repository.icr.ac.uk/handle/internal/1782
dc.description.abstractMouse models are important tools to decipher the molecular mechanisms of mammary carcinogenesis and to mimic the respective human disease. Despite sharing common phenotypic and genetic features, the proper translation of murine models to human breast cancer remains a challenging task. In a previous study we showed that in the SV40 transgenic WAP-T mice an active Met-pathway and epithelial-mesenchymal characteristics distinguish low- and high-grade mammary carcinoma. To assign these murine tumors to corresponding human tumors we here incorporated the analysis of expression of transcription factor (TF) coding genes and show that thereby a more accurate interspecies translation can be achieved. We describe a novel cross-species translation procedure and demonstrate that expression of unsupervised selected TFs, such as ELF5, HOXA5 and TFCP2L1, can clearly distinguish between the human molecular breast cancer subtypesor as, for example, expression of TFAP2B between yet unclassified subgroups. By integrating different levels of information like histology, gene set enrichment, expression of differentiation markers and TFs we conclude that tumors in WAP-T mice exhibit similarities to both, human basal-like and non-basal-like subtypes. We furthermore suggest that the low- and high-grade WAP-T tumor phenotypes might arise from distinct cells of tumor origin. Our results underscore the importance of TFs as common cross-species denominators in the regulatory networks underlying mammary carcinogenesis.
dc.format.extent1311 - 1322
dc.languageeng
dc.language.isoeng
dc.titleTranscription factors link mouse WAP-T mammary tumors with human breast cancer
dc.typeJournal Article
rioxxterms.licenseref.startdate2013-03
rioxxterms.typeJournal Article/Review
dc.relation.isPartOfINTERNATIONAL JOURNAL OF CANCER
pubs.notesISI Document Delivery No.: 078BG Times Cited: 0 Cited Reference Count: 51 Otto, Benjamin Streichert, Thomas Wegwitz, Florian Gevensleben, Heidrun Klaetschke, Kristin Wagener, Christoph Deppert, Wolfgang Tolstonog, Genrich V. Deutsche Forschungsgemeinschaft [De 212/23-1-3]; Deutsche Krebshilfe (Forschungsverbund "Tumorstammzellen"); Fonds der Chemischen Industrie Jung-Foundation for Science, Hamburg; Freie und Hansestadt Hamburg; Bundesministerium fur Gesundheit Grant sponsor: Deutsche Forschungsgemeinschaft; Grant number: De 212/23-1-3; Grant sponsors: Deutsche Krebshilfe (Forschungsverbund "Tumorstammzellen"), Fonds der Chemischen Industrie Jung-Foundation for Science, Hamburg, Freie und Hansestadt Hamburg, Bundesministerium fur Gesundheit. Wiley-blackwell Hoboken keywords: breast cancer transcription factors WAP-T transgenic mice molecular subtypes bioinformatics cross-species analysis ELF5 cell fate expression subtypes growth gland elf5 p53 identification tumorigenesis metastasis
pubs.notesNot known
pubs.organisational-group/ICR
pubs.organisational-group/ICR/Primary Group
pubs.organisational-group/ICR/Primary Group/ICR Divisions
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Breast Cancer Research
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Breast Cancer Research/Endocrinology
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Molecular Pathology
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Molecular Pathology/Endocrinology
pubs.organisational-group/ICR
pubs.organisational-group/ICR/Primary Group
pubs.organisational-group/ICR/Primary Group/ICR Divisions
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Breast Cancer Research
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Breast Cancer Research/Endocrinology
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Molecular Pathology
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Molecular Pathology/Endocrinology
pubs.volume132
pubs.embargo.termsNot known
icr.researchteamEndocrinologyen_US
dc.contributor.icrauthorGevensleben, Heidrunen


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