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dc.contributor.authorStratton, M
dc.date.accessioned2018-06-11T08:37:55Z
dc.date.issued2010-06
dc.identifier38
dc.identifier.citationScience Translational Medicine, 2010, 2
dc.identifier.urihttps://repository.icr.ac.uk/handle/internal/1783
dc.description.abstractDistinct molecular subtypes of breast carcinomas have been identified, but translation into clinical use has been limited. We have developed two platform-independent algorithms to explore genomic architectural distortion using array comparative genomic hybridization data to measure (i) whole-arm gains and losses [wholearm aberration index (WAAI)] and (ii) complex rearrangements [complex arm aberration index (CAAI)]. By applying CAAI and WAAI to data from 595 breast cancer patients, we were able to separate the cases into eight subgroups with different distributions of genomic distortion. Within each subgroup data from expression analyses, sequencing and ploidy indicated that progression occurs along separate paths into more complex genotypes. Histological grade had prognostic impact only in the luminal-related groups, whereas the complexity identified by CAAI had an overall independent prognostic power. This study emphasizes the relation among structural genomic alterations, molecular subtype, and clinical behavior and shows that objective score of genomic complexity (CAAI) is an independent prognostic marker in breast cancer.
dc.languageeng
dc.language.isoeng
dc.titleGenomic Architecture Characterizes Tumor Progression Paths and Fate in Breast Cancer Patients
dc.typeJournal Article
rioxxterms.licenseref.startdate2010-06
rioxxterms.typeJournal Article/Review
dc.relation.isPartOfScience Translational Medicine
pubs.notesISI Document Delivery No.: 735PH Times Cited: 2 Cited Reference Count: 68 Russnes, Hege G. Vollan, Hans Kristian Moen Lingjaerde, Ole Christian Krasnitz, Alexander Lundin, Par Naume, Bjorn Sorlie, Therese Borgen, Elin Rye, Inga H. Langerod, Anita Chin, Suet-Feung Teschendorff, Andrew E. Stephens, Philip J. Maner, Susanne Schlichting, Ellen Baumbusch, Lars O. Karesen, Rolf Stratton, Michael P. Wigler, Michael Caldas, Carlos Zetterberg, Anders Hicks, James Borresen-Dale, Anne-Lise Amer assoc advancement science Washington keywords: array-cgh molecular portraits genetic evolution estrogen-receptor mutation carriers bone-marrow high-grade subtypes carcinomas basal
pubs.notesNot known
pubs.organisational-group/ICR
pubs.organisational-group/ICR/Primary Group
pubs.organisational-group/ICR/Primary Group/ICR Divisions
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Breast Cancer Research
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Breast Cancer Research/Genetic Susceptibility
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Genetics and Epidemiology
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Genetics and Epidemiology/Genetic Susceptibility
pubs.organisational-group/ICR
pubs.organisational-group/ICR/Primary Group
pubs.organisational-group/ICR/Primary Group/ICR Divisions
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Breast Cancer Research
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Breast Cancer Research/Genetic Susceptibility
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Genetics and Epidemiology
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Genetics and Epidemiology/Genetic Susceptibility
pubs.volume2
pubs.embargo.termsNot known
pubs.oa-locationhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3972440/
icr.researchteamGenetic Susceptibilityen_US
dc.contributor.icrauthorStratton, Michaelen


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