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dc.date.accessioned2018-06-11T09:24:31Z
dc.date.issued2010-02
dc.identifier1
dc.identifier.citationBEST PRACTICE & RESEARCH CLINICAL OBSTETRICS & GYNAECOLOGY, 2010, 24 pp. 3 - 18
dc.identifier.urihttps://repository.icr.ac.uk/handle/internal/1789
dc.description.abstractCancers of the reproductive organs (i.e., ovaries, uterus and testes), like other cancers, occur as a result of a multi-stage interaction of genetic and environmental factors. A small proportion of cancers of the reproductive organs occur as part of a recognised cancer syndrome, as a result of inheritance of mutations in highly penetrant cancer susceptibility genes (e.g., BRCA1, BRCA2, MLH1 or MSH2). Recognition of individuals and families with inherited cancer predisposition syndromes and individuals at high risk due to familial cancer clustering is fundamentally important for the management and treatment of the current cancer and for future prevention of further cancers for the individual and their extended family. (C) 2009 Elsevier Ltd. All rights reserved.
dc.format.extent3 - 18
dc.languageeng
dc.language.isoeng
dc.publisherELSEVIER SCI LTD
dc.titleCancer genetics and reproduction
dc.typeJournal Article
rioxxterms.licenseref.startdate2010-02
rioxxterms.typeJournal Article/Review
dc.relation.isPartOfBEST PRACTICE & RESEARCH CLINICAL OBSTETRICS & GYNAECOLOGY
pubs.noteskeywords: hereditary cancer syndrome; ovarian cancer; endometrial cancer; BRCA1; BRCA2; MLH1; MSH2; hereditary non-polyposis colon cancer; lynch syndrome;NONPOLYPOSIS COLORECTAL-CANCER; FAMILIAL-OVARIAN-CANCER; BRCA2 MUTATION CARRIERS; PEUTZ-JEGHERS-SYNDROME; BILATERAL PROPHYLACTIC OOPHORECTOMY; HORMONE REPLACEMENT THERAPY; GENOME-WIDE ASSOCIATION; BREAST-CANCER; LYNCH-SYNDROME; ENDOMETRIAL CANCER
pubs.notesNot known
pubs.organisational-group/ICR
pubs.organisational-group/ICR
pubs.volume24
pubs.embargo.termsNot known
dc.contributor.icrauthorHanson, Helenen


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