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dc.contributor.authorShete, Sen_US
dc.contributor.authorHosking, FJen_US
dc.contributor.authorRobertson, LBen_US
dc.contributor.authorDobbins, SEen_US
dc.contributor.authorSanson, Men_US
dc.contributor.authorMalmer, Ben_US
dc.contributor.authorSimon, Men_US
dc.contributor.authorMarie, Yen_US
dc.contributor.authorBoisselier, Ben_US
dc.contributor.authorDelattre, JYen_US
dc.contributor.authorHoang-Xuan, Ken_US
dc.contributor.authorEl Hallani, Sen_US
dc.contributor.authorIdbaih, Aen_US
dc.contributor.authorZelenika, Den_US
dc.contributor.authorAndersson, Uen_US
dc.contributor.authorHenriksson, Ren_US
dc.contributor.authorBergenheim, ATen_US
dc.contributor.authorFeychting, Men_US
dc.contributor.authorLönn, Sen_US
dc.contributor.authorAhlbom, Aen_US
dc.contributor.authorSchramm, Jen_US
dc.contributor.authorLinnebank, Men_US
dc.contributor.authorHemminki, Ken_US
dc.contributor.authorKumar, Ren_US
dc.contributor.authorHepworth, SJen_US
dc.contributor.authorPrice, Aen_US
dc.contributor.authorArmstrong, Gen_US
dc.contributor.authorLiu, Yen_US
dc.contributor.authorGu, Xen_US
dc.contributor.authorYu, Ren_US
dc.contributor.authorLau, Cen_US
dc.contributor.authorSchoemaker, Men_US
dc.contributor.authorMuir, Ken_US
dc.contributor.authorSwerdlow, Aen_US
dc.contributor.authorLathrop, Men_US
dc.contributor.authorBondy, Men_US
dc.contributor.authorHoulston, RSen_US
dc.date.accessioned2018-06-11T09:56:59Z
dc.date.issued2009-08en_US
dc.identifier.citationNature genetics, 2009, 41 (8), pp. 899 - 904en_US
dc.identifier.issn1061-4036en_US
dc.identifier.urihttps://repository.icr.ac.uk/handle/internal/1796
dc.identifier.eissn1546-1718en_US
dc.identifier.doi10.1038/ng.407en_US
dc.description.abstractTo identify risk variants for glioma, we conducted a meta-analysis of two genome-wide association studies by genotyping 550K tagging SNPs in a total of 1,878 cases and 3,670 controls, with validation in three additional independent series totaling 2,545 cases and 2,953 controls. We identified five risk loci for glioma at 5p15.33 (rs2736100, TERT; P = 1.50 x 10(-17)), 8q24.21 (rs4295627, CCDC26; P = 2.34 x 10(-18)), 9p21.3 (rs4977756, CDKN2A-CDKN2B; P = 7.24 x 10(-15)), 20q13.33 (rs6010620, RTEL1; P = 2.52 x 10(-12)) and 11q23.3 (rs498872, PHLDB1; P = 1.07 x 10(-8)). These data show that common low-penetrance susceptibility alleles contribute to the risk of developing glioma and provide insight into disease causation of this primary brain tumor.en_US
dc.formatPrint-Electronicen_US
dc.format.extent899 - 904en_US
dc.languageengen_US
dc.language.isoengen_US
dc.subjectHumansen_US
dc.subjectGliomaen_US
dc.subjectGenetic Predisposition to Diseaseen_US
dc.subjectReproducibility of Resultsen_US
dc.subjectLinkage Disequilibriumen_US
dc.subjectPolymorphism, Single Nucleotideen_US
dc.subjectAllelesen_US
dc.subjectGenome-Wide Association Studyen_US
dc.titleGenome-wide association study identifies five susceptibility loci for glioma.en_US
dc.typeJournal Article
dcterms.dateAccepted2009-05-22en_US
rioxxterms.versionofrecord10.1038/ng.407en_US
rioxxterms.licenseref.startdate2009-08en_US
rioxxterms.typeJournal Article/Reviewen_US
dc.relation.isPartOfNature geneticsen_US
pubs.issue8en_US
pubs.notesNot knownen_US
pubs.organisational-group/ICR
pubs.organisational-group/ICR/Primary Group
pubs.organisational-group/ICR/Primary Group/ICR Divisions
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Breast Cancer Research
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Breast Cancer Research/Aetiological Epidemiology
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Genetics and Epidemiology
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Genetics and Epidemiology/Aetiological Epidemiology
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Genetics and Epidemiology/Molecular & Population Genetics
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Molecular Pathology
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Molecular Pathology/Molecular & Population Genetics
pubs.volume41en_US
pubs.embargo.termsNot knownen_US
pubs.oa-locationhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4501476/en_US
icr.researchteamAetiological Epidemiologyen_US
icr.researchteamMolecular & Population Geneticsen_US
dc.contributor.icrauthorHoulston, Richarden_US
dc.contributor.icrauthorSchoemaker, Minouken_US
dc.contributor.icrauthorSwerdlow, Anthonyen_US


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