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Somatic mutations of the histone H3K27 demethylase gene UTX in human cancer

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Publication Date
2009-05
ICR Author
Stratton, Michael
Author
Stratton, M
Type
Journal Article
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Abstract
Somatically acquired epigenetic changes are present in many cancers. Epigenetic regulation is maintained via post-translational modifications of core histones. Here, we describe inactivating somatic mutations in the histone lysine demethylase gene UTX, pointing to histone H3 lysine methylation deregulation in multiple tumor types. UTX reintroduction into cancer cells with inactivating UTX mutations resulted in slowing of proliferation and marked transcriptional changes. These data identify UTX as a new human cancer gene.
URL
https://repository.icr.ac.uk/handle/internal/1798
Open access location
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2873835/pdf/ukmss-30569.pdf
Collections
  • Breast Cancer Research
  • Genetics and Epidemiology
Research team
Genetic Susceptibility
License start date
2009-05
Citation
NATURE GENETICS, 2009, 41 pp. 521 - 523

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