Somatic mutations of the histone H3K27 demethylase gene UTX in human cancer
Publication Date
2009-05ICR Author
Author
Stratton, M
Type
Journal Article
Metadata
Show full item recordAbstract
Somatically acquired epigenetic changes are present in many cancers. Epigenetic regulation is maintained via post-translational modifications of core histones. Here, we describe inactivating somatic mutations in the histone lysine demethylase gene UTX, pointing to histone H3 lysine methylation deregulation in multiple tumor types. UTX reintroduction into cancer cells with inactivating UTX mutations resulted in slowing of proliferation and marked transcriptional changes. These data identify UTX as a new human cancer gene.
Open access location
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2873835/pdf/ukmss-30569.pdfCollections
Research team
Genetic Susceptibility
License start date
2009-05
Citation
NATURE GENETICS, 2009, 41 pp. 521 - 523