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dc.contributor.authorPeterlongo, P
dc.contributor.authorChang-Claude, J
dc.contributor.authorMoysich, KB
dc.contributor.authorRudolph, A
dc.contributor.authorSchmutzler, RK
dc.contributor.authorSimard, J
dc.contributor.authorSoucy, P
dc.contributor.authorEeles, RA
dc.contributor.authorEaston, DF
dc.contributor.authorHamann, U
dc.contributor.authorWilkening, S
dc.contributor.authorChen, B
dc.contributor.authorRookus, MA
dc.contributor.authorSchmidt, MK
dc.contributor.authorvan der Baan, FH
dc.contributor.authorSpurdle, AB
dc.contributor.authorWalker, LC
dc.contributor.authorLose, F
dc.contributor.authorMaia, A-T
dc.contributor.authorMontagna, M
dc.contributor.authorMatricardi, L
dc.contributor.authorLubinski, J
dc.contributor.authorJakubowska, A
dc.contributor.authorGómez Garcia, EB
dc.contributor.authorOlopade, OI
dc.contributor.authorNussbaum, RL
dc.contributor.authorNathanson, KL
dc.contributor.authorDomchek, SM
dc.contributor.authorRebbeck, TR
dc.contributor.authorArun, BK
dc.contributor.authorKarlan, BY
dc.contributor.authorOrsulic, S
dc.contributor.authorLester, J
dc.contributor.authorChung, WK
dc.contributor.authorMiron, A
dc.contributor.authorSouthey, MC
dc.contributor.authorGoldgar, DE
dc.contributor.authorBuys, SS
dc.contributor.authorJanavicius, R
dc.contributor.authorDorfling, CM
dc.contributor.authorvan Rensburg, EJ
dc.contributor.authorDing, YC
dc.contributor.authorNeuhausen, SL
dc.contributor.authorHansen, TVO
dc.contributor.authorGerdes, A-M
dc.contributor.authorEjlertsen, B
dc.contributor.authorJønson, L
dc.contributor.authorOsorio, A
dc.contributor.authorMartínez-Bouzas, C
dc.contributor.authorBenitez, J
dc.contributor.authorConway, EE
dc.contributor.authorBlazer, KR
dc.contributor.authorWeitzel, JN
dc.contributor.authorManoukian, S
dc.contributor.authorPeissel, B
dc.contributor.authorZaffaroni, D
dc.contributor.authorScuvera, G
dc.contributor.authorBarile, M
dc.contributor.authorFicarazzi, F
dc.contributor.authorMariette, F
dc.contributor.authorFortuzzi, S
dc.contributor.authorViel, A
dc.contributor.authorGiannini, G
dc.contributor.authorPapi, L
dc.contributor.authorMartayan, A
dc.contributor.authorTibiletti, MG
dc.contributor.authorRadice, P
dc.contributor.authorVratimos, A
dc.contributor.authorFostira, F
dc.contributor.authorGarber, JE
dc.contributor.authorDonaldson, A
dc.contributor.authorBrewer, C
dc.contributor.authorFoo, C
dc.contributor.authorEvans, DGR
dc.contributor.authorFrost, D
dc.contributor.authorEccles, D
dc.contributor.authorBrady, A
dc.contributor.authorCook, J
dc.contributor.authorTischkowitz, M
dc.contributor.authorAdlard, J
dc.contributor.authorBarwell, J
dc.contributor.authorWalker, L
dc.contributor.authorIzatt, L
dc.contributor.authorSide, LE
dc.contributor.authorKennedy, MJ
dc.contributor.authorRogers, MT
dc.contributor.authorPorteous, ME
dc.contributor.authorMorrison, PJ
dc.contributor.authorPlatte, R
dc.contributor.authorDavidson, R
dc.contributor.authorHodgson, SV
dc.contributor.authorEllis, S
dc.contributor.authorCole, T
dc.contributor.authorEMBRACE,
dc.contributor.authorGodwin, AK
dc.contributor.authorClaes, K
dc.contributor.authorVan Maerken, T
dc.contributor.authorMeindl, A
dc.contributor.authorGehrig, A
dc.contributor.authorSutter, C
dc.contributor.authorEngel, C
dc.contributor.authorNiederacher, D
dc.contributor.authorSteinemann, D
dc.contributor.authorPlendl, H
dc.contributor.authorKast, K
dc.contributor.authorRhiem, K
dc.contributor.authorDitsch, N
dc.contributor.authorArnold, N
dc.contributor.authorVaron-Mateeva, R
dc.contributor.authorWappenschmidt, B
dc.contributor.authorWang-Gohrke, S
dc.contributor.authorBressac-de Paillerets, B
dc.contributor.authorBuecher, B
dc.contributor.authorDelnatte, C
dc.contributor.authorHoudayer, C
dc.contributor.authorStoppa-Lyonnet, D
dc.contributor.authorDamiola, F
dc.contributor.authorCoupier, I
dc.contributor.authorBarjhoux, L
dc.contributor.authorVenat-Bouvet, L
dc.contributor.authorGolmard, L
dc.contributor.authorBoutry-Kryza, N
dc.contributor.authorSinilnikova, OM
dc.contributor.authorCaron, O
dc.contributor.authorPujol, P
dc.contributor.authorMazoyer, S
dc.contributor.authorBelotti, M
dc.contributor.authorGEMO Study Collaborators,
dc.contributor.authorPiedmonte, M
dc.contributor.authorFriedlander, ML
dc.contributor.authorRodriguez, GC
dc.contributor.authorCopeland, LJ
dc.contributor.authorde la Hoya, M
dc.contributor.authorSegura, PP
dc.contributor.authorNevanlinna, H
dc.contributor.authorAittomäki, K
dc.contributor.authorvan Os, TAM
dc.contributor.authorMeijers-Heijboer, HEJ
dc.contributor.authorvan der Hout, AH
dc.contributor.authorVreeswijk, MPG
dc.contributor.authorHoogerbrugge, N
dc.contributor.authorAusems, MGEM
dc.contributor.authorvan Doorn, HC
dc.contributor.authorCollée, JM
dc.contributor.authorHEBON,
dc.contributor.authorOlah, E
dc.contributor.authorDiez, O
dc.contributor.authorBlanco, I
dc.contributor.authorLazaro, C
dc.contributor.authorBrunet, J
dc.contributor.authorFeliubadalo, L
dc.contributor.authorCybulski, C
dc.contributor.authorGronwald, J
dc.contributor.authorDurda, K
dc.contributor.authorJaworska-Bieniek, K
dc.contributor.authorSukiennicki, G
dc.contributor.authorArason, A
dc.contributor.authorChiquette, J
dc.contributor.authorTeixeira, MR
dc.contributor.authorOlswold, C
dc.contributor.authorCouch, FJ
dc.contributor.authorLindor, NM
dc.contributor.authorWang, X
dc.contributor.authorSzabo, CI
dc.contributor.authorOffit, K
dc.contributor.authorCorines, M
dc.contributor.authorJacobs, L
dc.contributor.authorRobson, ME
dc.contributor.authorZhang, L
dc.contributor.authorJoseph, V
dc.contributor.authorBerger, A
dc.contributor.authorSinger, CF
dc.contributor.authorRappaport, C
dc.contributor.authorKaulich, DG
dc.contributor.authorPfeiler, G
dc.contributor.authorTea, M-KM
dc.contributor.authorPhelan, CM
dc.contributor.authorGreene, MH
dc.contributor.authorMai, PL
dc.contributor.authorRennert, G
dc.contributor.authorMulligan, AM
dc.contributor.authorGlendon, G
dc.contributor.authorTchatchou, S
dc.contributor.authorAndrulis, IL
dc.contributor.authorToland, AE
dc.contributor.authorBojesen, A
dc.contributor.authorPedersen, IS
dc.contributor.authorThomassen, M
dc.contributor.authorJensen, UB
dc.contributor.authorLaitman, Y
dc.contributor.authorRantala, J
dc.contributor.authorvon Wachenfeldt, A
dc.contributor.authorEhrencrona, H
dc.contributor.authorAskmalm, MS
dc.contributor.authorBorg, Å
dc.contributor.authorKuchenbaecker, KB
dc.contributor.authorMcGuffog, L
dc.contributor.authorBarrowdale, D
dc.contributor.authorHealey, S
dc.contributor.authorLee, A
dc.contributor.authorPharoah, PDP
dc.contributor.authorChenevix-Trench, G
dc.contributor.authorKConFab Investigators,
dc.contributor.authorAntoniou, AC
dc.contributor.authorFriedman, E
dc.date.accessioned2018-06-13T09:08:22Z
dc.date.issued2015-01-01
dc.identifier.citationCancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, 2015, 24 (1), pp. 308 - 316
dc.identifier.issn1055-9965
dc.identifier.urihttps://repository.icr.ac.uk/handle/internal/1848
dc.identifier.eissn1538-7755
dc.identifier.doi10.1158/1055-9965.epi-14-0532
dc.description.abstractBACKGROUND: BRCA1 and BRCA2 mutation carriers are at substantially increased risk for developing breast and ovarian cancer. The incomplete penetrance coupled with the variable age at diagnosis in carriers of the same mutation suggests the existence of genetic and nongenetic modifying factors. In this study, we evaluated the putative role of variants in many candidate modifier genes. METHODS: Genotyping data from 15,252 BRCA1 and 8,211 BRCA2 mutation carriers, for known variants (n = 3,248) located within or around 445 candidate genes, were available through the iCOGS custom-designed array. Breast and ovarian cancer association analysis was performed within a retrospective cohort approach. RESULTS: The observed P values of association ranged between 0.005 and 1.000. None of the variants was significantly associated with breast or ovarian cancer risk in either BRCA1 or BRCA2 mutation carriers, after multiple testing adjustments. CONCLUSION: There is little evidence that any of the evaluated candidate variants act as modifiers of breast and/or ovarian cancer risk in BRCA1 or BRCA2 mutation carriers. IMPACT: Genome-wide association studies have been more successful at identifying genetic modifiers of BRCA1/2 penetrance than candidate gene studies.
dc.formatPrint-Electronic
dc.format.extent308 - 316
dc.languageeng
dc.language.isoeng
dc.publisherAMER ASSOC CANCER RESEARCH
dc.rights.urihttps://www.rioxx.net/licenses/all-rights-reserved
dc.subjectEMBRACE
dc.subjectGEMO Study Collaborators
dc.subjectHEBON
dc.subjectKConFab Investigators
dc.subjectHumans
dc.subjectBreast Neoplasms
dc.subjectOvarian Neoplasms
dc.subjectRetrospective Studies
dc.subjectCohort Studies
dc.subjectMutation
dc.subjectPolymorphism, Single Nucleotide
dc.subjectGenes, BRCA1
dc.subjectGenes, BRCA2
dc.subjectAdult
dc.subjectFemale
dc.subjectYoung Adult
dc.titleCandidate genetic modifiers for breast and ovarian cancer risk in BRCA1 and BRCA2 mutation carriers.
dc.typeJournal Article
rioxxterms.versionofrecord10.1158/1055-9965.epi-14-0532
rioxxterms.licenseref.urihttps://www.rioxx.net/licenses/all-rights-reserved
rioxxterms.licenseref.startdate2015-01
rioxxterms.typeJournal Article/Review
dc.relation.isPartOfCancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology
pubs.issue1
pubs.notesNot known
pubs.organisational-group/ICR
pubs.organisational-group/ICR/Primary Group
pubs.organisational-group/ICR/Primary Group/ICR Divisions
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Genetics and Epidemiology
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Genetics and Epidemiology/Oncogenetics
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Radiotherapy and Imaging
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Radiotherapy and Imaging/Oncogenetics
pubs.organisational-group/ICR
pubs.organisational-group/ICR/Primary Group
pubs.organisational-group/ICR/Primary Group/ICR Divisions
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Genetics and Epidemiology
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Genetics and Epidemiology/Oncogenetics
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Radiotherapy and Imaging
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Radiotherapy and Imaging/Oncogenetics
pubs.publication-statusPublished
pubs.volume24
pubs.embargo.termsNot known
icr.researchteamOncogenetics
dc.contributor.icrauthorEeles, Rosalind


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