Verification that common variation at 2q37.1, 6p25.3, 11q24.1, 15q23, and 19q13.32 influences chronic lymphocytic leukaemia risk.
Date
2010-08ICR Author
Author
Crowther-Swanepoel, D
Mansouri, M
Enjuanes, A
Vega, A
Smedby, KE
Ruiz-Ponte, C
Jurlander, J
Juliusson, G
Montserrat, E
Catovsky, D
Campo, E
Carracedo, A
Rosenquist, R
Houlston, RS
Type
Journal Article
Metadata
Show full item recordAbstract
A recent genome wide association study of chronic lymphocytic leukaemia (CLL) provided evidence that common variation at 2q13 (rs17483466), 2q37.1 (rs13397985), 6p25.3 (rs872071), 11q24.1 (rs735665), 15q23 (rs7176508) and 19q13.32 (rs11083846) affects CLL risk. To verify and further explore the relationship between these variants and CLL risk we genotyped case-control datasets from Spain and Sweden (824 cases, 850 controls). Combined data provided statistically significant support for an association between genotypes at rs13397985, rs872071, rs735665, rs7176508 and rs11083846 and CLL risk. CLL risk increased with increasing numbers of risk alleles (P(trend) = 1.40 x 10(-15)), consistent with a polygenic model of disease susceptibility. These data validate the relationship between common variation and risk of CLL.
Collections
Subject
Chromosomes, Human, Pair 2
Chromosomes, Human, Pair 6
Chromosomes, Human, Pair 11
Chromosomes, Human, Pair 15
Chromosomes, Human, Pair 19
Humans
Chromosome Aberrations
Genetic Predisposition to Disease
Case-Control Studies
Gene Frequency
Genotype
Polymorphism, Single Nucleotide
Aged
Middle Aged
Female
Male
Leukemia, Lymphocytic, Chronic, B-Cell
Genome-Wide Association Study
Research team
Cancer Genomics
Language
eng
License start date
2010-08
Citation
British journal of haematology, 2010, 150 (4), pp. 473 - 479
Related items
Showing items related by title, author, creator and subject.
-
Molecular cytogenetic analysis consistently identifies translocations involving chromosomes 1, 2 and 15 in five embryonal rhabdomyosarcoma cell lines and a PAX-FOXO1A fusion gene negative alveolar rhabdomyosarcoma cell line.
Roberts, I; Gordon, A; Wang, R; Pritchard-Jones, K; Shipley, J; et al. (2001-01)Rhabdomyosarcoma in children is a "small round blue cell tumour" that displays skeletal muscle differentiation. Two main histological variants are recognised, alveolar (ARMS) and embryonal (ERMS) rhabdomyosarcoma. Whereas ... -
Sex-specific glioma genome-wide association study identifies new risk locus at 3p21.31 in females, and finds sex-differences in risk at 8q24.21.
Ostrom, QT; Kinnersley, B; Wrensch, MR; Eckel-Passow, JE; Armstrong, G; et al. (2018-05-09)Incidence of glioma is approximately 50% higher in males. Previous analyses have examined exposures related to sex hormones in women as potential protective factors for these tumors, with inconsistent results. Previous ... -
A genome-wide association study identifies risk loci for childhood acute lymphoblastic leukemia at 10q26.13 and 12q23.1.
Vijayakrishnan, J; Kumar, R; Henrion, MYR; Moorman, AV; Rachakonda, PS; et al. (2017-03)Genome-wide association studies (GWASs) have shown that common genetic variation contributes to the heritable risk of childhood acute lymphoblastic leukemia (ALL). To identify new susceptibility loci for the largest subtype ...