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Verification that common variation at 2q37.1, 6p25.3, 11q24.1, 15q23, and 19q13.32 influences chronic lymphocytic leukaemia risk.

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Date
2010-08
ICR Author
Houlston, Richard
Author
Crowther-Swanepoel, D
Mansouri, M
Enjuanes, A
Vega, A
Smedby, KE
Ruiz-Ponte, C
Jurlander, J
Juliusson, G
Montserrat, E
Catovsky, D
Campo, E
Carracedo, A
Rosenquist, R
Houlston, RS
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Type
Journal Article
Metadata
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Abstract
A recent genome wide association study of chronic lymphocytic leukaemia (CLL) provided evidence that common variation at 2q13 (rs17483466), 2q37.1 (rs13397985), 6p25.3 (rs872071), 11q24.1 (rs735665), 15q23 (rs7176508) and 19q13.32 (rs11083846) affects CLL risk. To verify and further explore the relationship between these variants and CLL risk we genotyped case-control datasets from Spain and Sweden (824 cases, 850 controls). Combined data provided statistically significant support for an association between genotypes at rs13397985, rs872071, rs735665, rs7176508 and rs11083846 and CLL risk. CLL risk increased with increasing numbers of risk alleles (P(trend) = 1.40 x 10(-15)), consistent with a polygenic model of disease susceptibility. These data validate the relationship between common variation and risk of CLL.
URI
https://repository.icr.ac.uk/handle/internal/1859
DOI
https://doi.org/10.1111/j.1365-2141.2010.08270.x
Collections
  • Genetics and Epidemiology
Subject
Chromosomes, Human, Pair 2
Chromosomes, Human, Pair 6
Chromosomes, Human, Pair 11
Chromosomes, Human, Pair 15
Chromosomes, Human, Pair 19
Humans
Chromosome Aberrations
Genetic Predisposition to Disease
Case-Control Studies
Gene Frequency
Genotype
Polymorphism, Single Nucleotide
Aged
Middle Aged
Female
Male
Leukemia, Lymphocytic, Chronic, B-Cell
Genome-Wide Association Study
Research team
Cancer Genomics
Language
eng
License start date
2010-08
Citation
British journal of haematology, 2010, 150 (4), pp. 473 - 479

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