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dc.contributor.authorSwerdlow, AJ
dc.contributor.authorHermon, C
dc.contributor.authorJacobs, PA
dc.contributor.authorAlberman, E
dc.contributor.authorBeral, V
dc.contributor.authorDaker, M
dc.contributor.authorFordyce, A
dc.contributor.authorYouings, S
dc.date.accessioned2018-06-14T10:24:35Z
dc.date.issued2001-03
dc.identifier.citationAnnals of human genetics, 2001, 65 (Pt 2), pp. 177 - 188
dc.identifier.issn0003-4800
dc.identifier.urihttps://repository.icr.ac.uk/handle/internal/1880
dc.identifier.eissn1469-1809
dc.identifier.doi10.1017/s0003480001008569
dc.description.abstractMortality and cancer incidence were assessed in a cohort of 1373 patients with numerical sex chromosome abnormalities diagnosed at three cytogenetics centres in Britain during 1959-90, and were compared with expectations from national rates. Four hundred patients with Turner's syndrome were followed, of whom 62 died, with a relative risk (RR) of death of 4.16 (95% confidence interval (CI) 3.22-5.39). Turner's syndrome patients had greatly raised risks of death from diseases of the nervous, cardiovascular, respiratory, digestive and genitourinary systems. One hundred and sixty three deaths occurred among 646 patients with Klinefelter's syndrome with a 47,XXY constitution, giving an RR of 1.63 (1.40-1.91). Mortality in these patients was significantly raised from diabetes and diseases of the cardiovascular, respiratory and digestive systems. There was also significantly increased mortality for patients with X polysomy (RR = 2.11 (1.43-3.02)) and Y polysomy (RR = 1.90 (1.20-2.85)), the former with significantly increased mortality from cardiovascular disease and the latter from respiratory disease. The only significantly raised risks of cancer incidence or mortality in the cohort were for lung cancer and breast cancer in patients with Klinefelter's syndrome with a 47,XXY constitution, and non-Hodgkin's lymphoma in men with more than three sex chromosomes.
dc.formatPrint
dc.format.extent177 - 188
dc.languageeng
dc.language.isoeng
dc.subjectHumans
dc.subjectNeoplasms
dc.subjectTurner Syndrome
dc.subjectKlinefelter Syndrome
dc.subjectAneuploidy
dc.subjectSex Chromosome Aberrations
dc.subjectCause of Death
dc.subjectCohort Studies
dc.subjectFollow-Up Studies
dc.subjectAdolescent
dc.subjectAdult
dc.subjectAged
dc.subjectAged, 80 and over
dc.subjectMiddle Aged
dc.subjectChild
dc.subjectChild, Preschool
dc.subjectFemale
dc.subjectMale
dc.titleMortality and cancer incidence in persons with numerical sex chromosome abnormalities: a cohort study.
dc.typeJournal Article
rioxxterms.versionofrecord10.1017/s0003480001008569
rioxxterms.licenseref.startdate2001-03
rioxxterms.typeJournal Article/Review
dc.relation.isPartOfAnnals of human genetics
pubs.issuePt 2
pubs.notesNot known
pubs.organisational-group/ICR
pubs.organisational-group/ICR/Primary Group
pubs.organisational-group/ICR/Primary Group/ICR Divisions
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Breast Cancer Research
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Breast Cancer Research/Aetiological Epidemiology
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Genetics and Epidemiology
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Genetics and Epidemiology/Aetiological Epidemiology
pubs.organisational-group/ICR
pubs.organisational-group/ICR/Primary Group
pubs.organisational-group/ICR/Primary Group/ICR Divisions
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Breast Cancer Research
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Breast Cancer Research/Aetiological Epidemiology
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Genetics and Epidemiology
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Genetics and Epidemiology/Aetiological Epidemiology
pubs.publication-statusPublished
pubs.volume65
pubs.embargo.termsNot known
icr.researchteamAetiological Epidemiologyen_US
dc.contributor.icrauthorSwerdlow, Anthonyen


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