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dc.contributor.authorHermon, C
dc.contributor.authorAlberman, E
dc.contributor.authorBeral, V
dc.contributor.authorSwerdlow, AJ
dc.date.accessioned2018-06-14T10:25:42Z
dc.date.issued2001-03
dc.identifier.citationAnnals of human genetics, 2001, 65 (Pt 2), pp. 167 - 176
dc.identifier.issn0003-4800
dc.identifier.urihttps://repository.icr.ac.uk/handle/internal/1881
dc.identifier.eissn1469-1809
dc.identifier.doi10.1017/s0003480001008508
dc.description.abstractA cohort study of 1425 persons with Down's syndrome (DS), and of their parents (447 mothers, 435 fathers) and siblings (1176), was set up to investigate death rates from various causes and cancer incidence patterns. In individuals with DS the all-cause death rate was six times that of the national population (SMR = 622: 95% CI 559-693), the excess being attributable to many different causes. These included: leukaemia (SMR = 1304: 95% CI 651-2334); diabetes mellitus (SMR = 982: 95% CI 267-2515); Alzheimer's disease (SMR = 22028: 95% CI 7137-51326); epilepsy (SMR = 1727: 95% CI 744-3403); and congenital anomalies (SMR = 4987: 95% CI 4175-5955). The overall survival showed marked improvements for successive birth cohorts, particularly at young ages. For mothers and fathers of persons with DS, all-cause death rates were 20% lower than national rates and there were no significant excesses from any specific cause. For siblings, all-cause death rates were similar to national rates; the only condition with a significantly raised mortality ratio was colo-rectal cancer (SMR = 793: 95% CI 216-2031), but this may well be a chance finding.
dc.formatPrint
dc.format.extent167 - 176
dc.languageeng
dc.language.isoeng
dc.subjectHumans
dc.subjectNeoplasms
dc.subjectDown Syndrome
dc.subjectCause of Death
dc.subjectCohort Studies
dc.subjectNuclear Family
dc.subjectParents
dc.subjectAdolescent
dc.subjectAdult
dc.subjectAged
dc.subjectMiddle Aged
dc.subjectChild
dc.subjectChild, Preschool
dc.subjectInfant
dc.subjectInfant, Newborn
dc.subjectEngland
dc.subjectScotland
dc.subjectFemale
dc.subjectMale
dc.subjectBias
dc.titleMortality and cancer incidence in persons with Down's syndrome, their parents and siblings.
dc.typeJournal Article
rioxxterms.versionofrecord10.1017/s0003480001008508
rioxxterms.licenseref.startdate2001-03
rioxxterms.typeJournal Article/Review
dc.relation.isPartOfAnnals of human genetics
pubs.issuePt 2
pubs.notesNot known
pubs.organisational-group/ICR
pubs.organisational-group/ICR/Primary Group
pubs.organisational-group/ICR/Primary Group/ICR Divisions
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Breast Cancer Research
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Breast Cancer Research/Aetiological Epidemiology
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Genetics and Epidemiology
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Genetics and Epidemiology/Aetiological Epidemiology
pubs.organisational-group/ICR
pubs.organisational-group/ICR/Primary Group
pubs.organisational-group/ICR/Primary Group/ICR Divisions
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Breast Cancer Research
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Breast Cancer Research/Aetiological Epidemiology
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Genetics and Epidemiology
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Genetics and Epidemiology/Aetiological Epidemiology
pubs.publication-statusPublished
pubs.volume65
pubs.embargo.termsNot known
icr.researchteamAetiological Epidemiologyen_US
dc.contributor.icrauthorSwerdlow, Anthonyen


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