dc.contributor.author | Went, M | |
dc.contributor.author | Sud, A | |
dc.contributor.author | Försti, A | |
dc.contributor.author | Halvarsson, B-M | |
dc.contributor.author | Weinhold, N | |
dc.contributor.author | Kimber, S | |
dc.contributor.author | van Duin, M | |
dc.contributor.author | Thorleifsson, G | |
dc.contributor.author | Holroyd, A | |
dc.contributor.author | Johnson, DC | |
dc.contributor.author | Li, N | |
dc.contributor.author | Orlando, G | |
dc.contributor.author | Law, PJ | |
dc.contributor.author | Ali, M | |
dc.contributor.author | Chen, B | |
dc.contributor.author | Mitchell, JS | |
dc.contributor.author | Gudbjartsson, DF | |
dc.contributor.author | Kuiper, R | |
dc.contributor.author | Stephens, OW | |
dc.contributor.author | Bertsch, U | |
dc.contributor.author | Broderick, P | |
dc.contributor.author | Campo, C | |
dc.contributor.author | Bandapalli, OR | |
dc.contributor.author | Einsele, H | |
dc.contributor.author | Gregory, WA | |
dc.contributor.author | Gullberg, U | |
dc.contributor.author | Hillengass, J | |
dc.contributor.author | Hoffmann, P | |
dc.contributor.author | Jackson, GH | |
dc.contributor.author | Jöckel, K-H | |
dc.contributor.author | Johnsson, E | |
dc.contributor.author | Kristinsson, SY | |
dc.contributor.author | Mellqvist, U-H | |
dc.contributor.author | Nahi, H | |
dc.contributor.author | Easton, D | |
dc.contributor.author | Pharoah, P | |
dc.contributor.author | Dunning, A | |
dc.contributor.author | Peto, J | |
dc.contributor.author | Canzian, F | |
dc.contributor.author | Swerdlow, A | |
dc.contributor.author | Eeles, RA | |
dc.contributor.author | Kote-Jarai, Z | |
dc.contributor.author | Muir, K | |
dc.contributor.author | Pashayan, N | |
dc.contributor.author | Nickel, J | |
dc.contributor.author | Nöthen, MM | |
dc.contributor.author | Rafnar, T | |
dc.contributor.author | Ross, FM | |
dc.contributor.author | da Silva Filho, MI | |
dc.contributor.author | Thomsen, H | |
dc.contributor.author | Turesson, I | |
dc.contributor.author | Vangsted, A | |
dc.contributor.author | Andersen, NF | |
dc.contributor.author | Waage, A | |
dc.contributor.author | Walker, BA | |
dc.contributor.author | Wihlborg, A-K | |
dc.contributor.author | Broyl, A | |
dc.contributor.author | Davies, FE | |
dc.contributor.author | Thorsteinsdottir, U | |
dc.contributor.author | Langer, C | |
dc.contributor.author | Hansson, M | |
dc.contributor.author | Goldschmidt, H | |
dc.contributor.author | Kaiser, M | |
dc.contributor.author | Sonneveld, P | |
dc.contributor.author | Stefansson, K | |
dc.contributor.author | Morgan, GJ | |
dc.contributor.author | Hemminki, K | |
dc.contributor.author | Nilsson, B | |
dc.contributor.author | Houlston, RS | |
dc.contributor.author | PRACTICAL consortium, | |
dc.coverage.spatial | England | |
dc.date.accessioned | 2018-06-25T10:25:38Z | |
dc.date.issued | 2018-09-13 | |
dc.identifier | https://www.ncbi.nlm.nih.gov/pubmed/30213928 | |
dc.identifier | 10.1038/s41467-018-04989-w | |
dc.identifier.citation | Nat Commun, 2018, 9 (1), pp. 3707 - ? | |
dc.identifier.uri | https://repository.icr.ac.uk/handle/internal/1900 | |
dc.identifier.eissn | 2041-1723 | |
dc.identifier.doi | 10.1038/s41467-018-04989-w | |
dc.description.abstract | Genome-wide association studies (GWAS) have transformed our understanding of susceptibility to multiple myeloma (MM), but much of the heritability remains unexplained. We report a new GWAS, a meta-analysis with previous GWAS and a replication series, totalling 9974 MM cases and 247,556 controls of European ancestry. Collectively, these data provide evidence for six new MM risk loci, bringing the total number to 23. Integration of information from gene expression, epigenetic profiling and in situ Hi-C data for the 23 risk loci implicate disruption of developmental transcriptional regulators as a basis of MM susceptibility, compatible with altered B-cell differentiation as a key mechanism. Dysregulation of autophagy/apoptosis and cell cycle signalling feature as recurrently perturbed pathways. Our findings provide further insight into the biological basis of MM. | |
dc.format.extent | 3707 - ? | |
dc.language | eng | |
dc.language.iso | eng | |
dc.publisher | NATURE PUBLISHING GROUP | |
dc.relation.isreplacedby | internal/2812 | |
dc.relation.isreplacedby | https://repository.icr.ac.uk/handle/internal/2812 | |
dc.rights.uri | https://creativecommons.org/licenses/by/4.0 | |
dc.title | Identification of multiple risk loci and regulatory mechanisms influencing susceptibility to multiple myeloma. | |
dc.type | Journal Article | |
dcterms.dateAccepted | 2018-06-06 | |
rioxxterms.versionofrecord | 10.1038/s41467-018-04989-w | |
rioxxterms.licenseref.uri | https://creativecommons.org/licenses/by/4.0 | |
rioxxterms.licenseref.startdate | 2018-09-13 | |
rioxxterms.type | Journal Article/Review | |
dc.relation.isPartOf | Nat Commun | |
pubs.issue | 1 | |
pubs.notes | Not known | |
pubs.organisational-group | /ICR | |
pubs.organisational-group | /ICR/Primary Group | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Genetics and Epidemiology | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Genetics and Epidemiology/Molecular & Population Genetics | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Genetics and Epidemiology/Oncogenetics | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Molecular Pathology | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Molecular Pathology/Molecular & Population Genetics | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Molecular Pathology/Myeloma Group | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Radiotherapy and Imaging | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Radiotherapy and Imaging/Oncogenetics | |
pubs.publication-status | Published online | |
pubs.volume | 9 | |
pubs.embargo.terms | Not known | |
icr.researchteam | Molecular & Population Genetics | |
icr.researchteam | Myeloma Group | |
icr.researchteam | Oncogenetics | |
dc.contributor.icrauthor | Went, Molly | |
dc.contributor.icrauthor | Sud, Amit | |
dc.contributor.icrauthor | Johnson, David | |
dc.contributor.icrauthor | Law, Philip | |
dc.contributor.icrauthor | Broderick, Peter | |
dc.contributor.icrauthor | Swerdlow, Anthony | |
dc.contributor.icrauthor | Eeles, Rosalind | |
dc.contributor.icrauthor | Kote-Jarai, Zsofia | |
dc.contributor.icrauthor | Kaiser, Martin | |
dc.contributor.icrauthor | Houlston, Richard | |