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dc.contributor.authorGilbert, DC
dc.contributor.authorChandler, I
dc.contributor.authorSummersgill, B
dc.contributor.authorMcIntyre, A
dc.contributor.authorMissiaglia, E
dc.contributor.authorGoddard, NC
dc.contributor.authorHuddart, RA
dc.contributor.authorShipley, J
dc.date.accessioned2018-06-25T13:31:07Z
dc.date.issued2011-08
dc.identifier.citationInternational journal of andrology, 2011, 34 (4 Pt 2), pp. e114 - e121
dc.identifier.issn0105-6263
dc.identifier.urihttps://repository.icr.ac.uk/handle/internal/1903
dc.identifier.eissn1365-2605
dc.identifier.doi10.1111/j.1365-2605.2011.01161.x
dc.description.abstractTesticular germ-cell tumours (TGCT) are the most frequent solid tumour to affect young Caucasian adult males and have increased in incidence over recent decades. In clinical stage I non-seminomas, (NSGCT) histological vascular invasion (VI) is a prognostic factor for metastatic relapse. Using array comparative genomic hybridization, we have previously shown that the presence of VI is associated with gain of a region at 17q12, containing a cluster of genes encoding inflammatory cytokines. We here confirm this finding using fluorescence in situ hybridization (FISH) demonstrating gain in 12 out of 42 (29%) assessable samples. Interrogation of previously published expression microarray data suggests that of the genes contained within this region, CCL2 [monocyte chemoattractant protein 1 (MCP1)] is frequently overexpressed in TGCT. Immunohistochemistry confirms this finding in a collection of 67 clinical stage I NSGCT, demonstrating an association with the presence of VI (p=0.049) that was not seen with VEGF-A, MMP2 or MMP9, although all were frequently expressed. This work gives further insight into the mechanisms involved in invasion in this tumour type, which may ultimately have implications for the management of patients with stage I disease.
dc.formatPrint-Electronic
dc.format.extente114 - e121
dc.languageeng
dc.language.isoeng
dc.subjectChromosomes, Human, Pair 17
dc.subjectHumans
dc.subjectNeoplasms, Germ Cell and Embryonal
dc.subjectTesticular Neoplasms
dc.subjectNeovascularization, Pathologic
dc.subjectVascular Endothelial Growth Factor A
dc.subjectNeoplasm Staging
dc.subjectPrognosis
dc.subjectOligonucleotide Array Sequence Analysis
dc.subjectIn Situ Hybridization, Fluorescence
dc.subjectGenome, Human
dc.subjectAdolescent
dc.subjectAdult
dc.subjectMiddle Aged
dc.subjectMale
dc.subjectMatrix Metalloproteinase 2
dc.subjectMatrix Metalloproteinase 9
dc.subjectChemokine CCL2
dc.subjectBiomarkers, Tumor
dc.titleGenomic gain and over expression of CCL2 correlate with vascular invasion in stage I non-seminomatous testicular germ-cell tumours.
dc.typeJournal Article
rioxxterms.versionofrecord10.1111/j.1365-2605.2011.01161.x
rioxxterms.licenseref.startdate2011-08
rioxxterms.typeJournal Article/Review
dc.relation.isPartOfInternational journal of andrology
pubs.issue4 Pt 2
pubs.notesNot known
pubs.organisational-group/ICR
pubs.organisational-group/ICR/Primary Group
pubs.organisational-group/ICR/Primary Group/ICR Divisions
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Cancer Therapeutics
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Cancer Therapeutics/Sarcoma Molecular Pathology
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Molecular Pathology
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Molecular Pathology/Sarcoma Molecular Pathology
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Radiotherapy and Imaging
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Radiotherapy and Imaging/Clinical Academic Radiotherapy (Huddart)
pubs.organisational-group/ICR
pubs.organisational-group/ICR/Primary Group
pubs.organisational-group/ICR/Primary Group/ICR Divisions
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Cancer Therapeutics
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Cancer Therapeutics/Sarcoma Molecular Pathology
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Molecular Pathology
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Molecular Pathology/Sarcoma Molecular Pathology
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Radiotherapy and Imaging
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Radiotherapy and Imaging/Clinical Academic Radiotherapy (Huddart)
pubs.publication-statusPublished
pubs.volume34
pubs.embargo.termsNot known
icr.researchteamSarcoma Molecular Pathologyen_US
icr.researchteamClinical Academic Radiotherapy (Huddart)en_US
dc.contributor.icrauthorShipley, Janeten
dc.contributor.icrauthorGoddard, Neil Christopheren
dc.contributor.icrauthorHuddart, Roberten


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