Thalidomide is highly effective in a patient with meningeal acute myeloid leukaemia
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Thalidomide is highly effective in a patient with meningeal acute myeloid leukaemia. We report a case of secondary acute myeloid leukaemia (AML) following high dose therapy for diffuse large B-cell non- Hodgkin's lymphoma (NHL) who developed meningeal leukaemia. This was refractory to systemic and intrathecal chemotherapy and cranial irradiation. Thalidomide has been reported to have anti-AML activity and appears to cross the blood brain barrier (BBB). We, therefore, attempted a trial of oral Thalidomide and achieved rapid biochemical and cytological remission with a short course. The patient, however, progressed systemically and succumbed to her illness.
acute myeloid leukaemia (AML) meningeal myelodysplasia non- Hodgkin's lymphoma (NHL) thalidomide acute myelogenous leukemia lymphoid malignancies brain transplantation myelodysplasia therapies
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LEUKEMIA & LYMPHOMA, 2004, 45 (1), pp. 179 - 181