Inhibiting the phosphoinositide 3-kinase pathway for cancer treatment.
Publication Date
2004-04ICR Author
Author
Workman, P
Type
Journal Article
Metadata
Show full item recordAbstract
There is extensive evidence from the molecular and genomic analysis of human cancers that the PI 3-kinase (phosphoinositide 3-kinase)-Akt/PKB (protein kinase B) pathway is deregulated in malignant progression. Furthermore, the causal involvement of PI 3-kinase is supported by gene-knockout mouse models. Prototype inhibitors show evidence of anticancer activity in vitro and in vivo animal models. The recent development of isoform-selective inhibitors shows considerable promise for cancer treatment.
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Version of record
Subject
Animals
Mice, Knockout
Humans
Mice
Neoplasms
Disease Models, Animal
Disease Progression
Protein Isoforms
Antineoplastic Agents
Enzyme Inhibitors
Genome
Models, Chemical
Phosphatidylinositol 3-Kinases
Language
eng
License start date
2004-04
Citation
Biochemical Society transactions, 2004, 32 (Pt 2), pp. 393 - 396