Inhibiting the phosphoinositide 3-kinase pathway for cancer treatment.
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There is extensive evidence from the molecular and genomic analysis of human cancers that the PI 3-kinase (phosphoinositide 3-kinase)-Akt/PKB (protein kinase B) pathway is deregulated in malignant progression. Furthermore, the causal involvement of PI 3-kinase is supported by gene-knockout mouse models. Prototype inhibitors show evidence of anticancer activity in vitro and in vivo animal models. The recent development of isoform-selective inhibitors shows considerable promise for cancer treatment.
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Disease Models, Animal
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Biochemical Society transactions, 2004, 32 (Pt 2), pp. 393 - 396