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dc.contributor.authorKyriazi, S
dc.contributor.authorNye, E
dc.contributor.authorStamp, G
dc.contributor.authorCollins, DJ
dc.contributor.authorKaye, SB
dc.contributor.authordeSouza, NM
dc.date.accessioned2018-06-26T10:38:24Z
dc.date.issued2010-01
dc.identifier.citationCancer biomarkers : section A of Disease markers, 2010, 7 (4), pp. 201 - 210
dc.identifier.issn1574-0153
dc.identifier.urihttps://repository.icr.ac.uk/handle/internal/1932
dc.identifier.eissn1875-8592
dc.identifier.doi10.3233/cbm-2010-0194
dc.description.abstractThis study correlates apparent diffusion coefficients (ADCs) from Diffusion-weighted Imaging (DWI) in primary ovarian tumours and their omental metastases following neoadjuvant chemotherapy with epithelial and stromal densities in order to relate them to histological composition. Eight patients underwent DWI at 1.5 T with four b-values (0, 600, 900, and 1,050 s/mm(2))at baseline and after one and three cycles of platinum-based chemotherapy. Mean ADCs were calculated at each timepoint from solid tumour at ovarian and omental sites. Specimens from 15 corresponding lesions (8 ovarian, 7 omental), obtained at interval debulking surgery, were stained immunohistochemically to quantify epithelial and stromal components. End-of-treatment ADC was correlated with epithelial and stromal densities. Longitudinal changes in ADC with treatment were compared between primary and metastatic lesions using parametric tests. No baseline differences in ADC between primary and metastatic sites were seen. Mean ADC increased significantly from baseline after both first and third cycle (P < 0.001) in both ovarian and omental lesions. ADC and total epithelial plus stromal density (lesion cellularity) were negatively correlated in ovarian lesions (r= -0.79, P=0.02) but not in omental metastases or when both sites were considered together. However, ADC and epithelial density were negatively correlated in ovarian (r=- 0.78, P=0.02) and omental lesions (r=-0.75, P=0.04) and when both sites were considered together (r=-0.77, P< 0.001). There was no significant correlation between ADC and stromal density. Thus ADC reflects mainly epithelial content in advanced ovarian cancer and is not solely a function of lesion cellularity.
dc.formatPrint
dc.format.extent201 - 210
dc.languageeng
dc.language.isoeng
dc.subjectStromal Cells
dc.subjectEpithelial Cells
dc.subjectHumans
dc.subjectOvarian Neoplasms
dc.subjectAntineoplastic Agents
dc.subjectDiffusion Magnetic Resonance Imaging
dc.subjectNeoplasm Staging
dc.subjectNeoadjuvant Therapy
dc.subjectDensitometry
dc.subjectAdult
dc.subjectAged
dc.subjectMiddle Aged
dc.subjectFemale
dc.titleValue of diffusion-weighted imaging for assessing site-specific response of advanced ovarian cancer to neoadjuvant chemotherapy: correlation of apparent diffusion coefficients with epithelial and stromal densities on histology.
dc.typeJournal Article
rioxxterms.versionofrecord10.3233/cbm-2010-0194
rioxxterms.licenseref.startdate2010-01
rioxxterms.typeJournal Article/Review
dc.relation.isPartOfCancer biomarkers : section A of Disease markers
pubs.issue4
pubs.notesNot known
pubs.organisational-group/ICR
pubs.organisational-group/ICR/Primary Group
pubs.organisational-group/ICR/Primary Group/ICR Divisions
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Closed research teams
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Closed research teams/Experimental Pathology
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Closed research teams/Medicine Drug Development Unit (Kaye)
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Radiotherapy and Imaging
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Radiotherapy and Imaging/Magnetic Resonance
pubs.organisational-group/ICR/Primary Group/Royal Marsden Clinical Units
pubs.organisational-group/ICR
pubs.organisational-group/ICR/Primary Group
pubs.organisational-group/ICR/Primary Group/ICR Divisions
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Closed research teams
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Closed research teams/Experimental Pathology
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Closed research teams/Medicine Drug Development Unit (Kaye)
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Radiotherapy and Imaging
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Radiotherapy and Imaging/Magnetic Resonance
pubs.organisational-group/ICR/Primary Group/Royal Marsden Clinical Units
pubs.publication-statusPublished
pubs.volume7
pubs.embargo.termsNot known
icr.researchteamExperimental Pathologyen_US
icr.researchteamMedicine Drug Development Unit (Kaye)en_US
icr.researchteamMagnetic Resonanceen_US
dc.contributor.icrauthorStamp, Gordonen
dc.contributor.icrauthorKaye, Stanley Bernarden
dc.contributor.icrauthordeSouza, Nanditaen


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