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dc.contributor.authorKyriazi, Sen_US
dc.contributor.authorNye, Een_US
dc.contributor.authorStamp, Gen_US
dc.contributor.authorCollins, DJen_US
dc.contributor.authorKaye, SBen_US
dc.contributor.authordeSouza, NMen_US
dc.identifier.citationCancer biomarkers : section A of Disease markers, 2010, 7 (4), pp. 201 - 210en_US
dc.description.abstractThis study correlates apparent diffusion coefficients (ADCs) from Diffusion-weighted Imaging (DWI) in primary ovarian tumours and their omental metastases following neoadjuvant chemotherapy with epithelial and stromal densities in order to relate them to histological composition. Eight patients underwent DWI at 1.5 T with four b-values (0, 600, 900, and 1,050 s/mm(2))at baseline and after one and three cycles of platinum-based chemotherapy. Mean ADCs were calculated at each timepoint from solid tumour at ovarian and omental sites. Specimens from 15 corresponding lesions (8 ovarian, 7 omental), obtained at interval debulking surgery, were stained immunohistochemically to quantify epithelial and stromal components. End-of-treatment ADC was correlated with epithelial and stromal densities. Longitudinal changes in ADC with treatment were compared between primary and metastatic lesions using parametric tests. No baseline differences in ADC between primary and metastatic sites were seen. Mean ADC increased significantly from baseline after both first and third cycle (P < 0.001) in both ovarian and omental lesions. ADC and total epithelial plus stromal density (lesion cellularity) were negatively correlated in ovarian lesions (r= -0.79, P=0.02) but not in omental metastases or when both sites were considered together. However, ADC and epithelial density were negatively correlated in ovarian (r=- 0.78, P=0.02) and omental lesions (r=-0.75, P=0.04) and when both sites were considered together (r=-0.77, P< 0.001). There was no significant correlation between ADC and stromal density. Thus ADC reflects mainly epithelial content in advanced ovarian cancer and is not solely a function of lesion cellularity.en_US
dc.format.extent201 - 210en_US
dc.subjectStromal Cellsen_US
dc.subjectEpithelial Cellsen_US
dc.subjectOvarian Neoplasmsen_US
dc.subjectAntineoplastic Agentsen_US
dc.subjectDiffusion Magnetic Resonance Imagingen_US
dc.subjectNeoplasm Stagingen_US
dc.subjectNeoadjuvant Therapyen_US
dc.subjectMiddle Ageden_US
dc.titleValue of diffusion-weighted imaging for assessing site-specific response of advanced ovarian cancer to neoadjuvant chemotherapy: correlation of apparent diffusion coefficients with epithelial and stromal densities on histology.en_US
dc.typeJournal Article
rioxxterms.typeJournal Article/Reviewen_US
dc.relation.isPartOfCancer biomarkers : section A of Disease markersen_US
pubs.notesNot knownen_US
pubs.organisational-group/ICR/Primary Group
pubs.organisational-group/ICR/Primary Group/ICR Divisions
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Closed research teams
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Closed research teams/Experimental Pathology
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Closed research teams/Medicine Drug Development Unit (Kaye)
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Radiotherapy and Imaging
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Radiotherapy and Imaging/Magnetic Resonance
pubs.organisational-group/ICR/Primary Group/Royal Marsden Clinical Units
pubs.embargo.termsNot knownen_US
icr.researchteamExperimental Pathologyen_US
icr.researchteamMedicine Drug Development Unit (Kaye)en_US
icr.researchteamMagnetic Resonanceen_US
dc.contributor.icrauthorKaye, Stanley Bernarden_US
dc.contributor.icrauthordeSouza, Nanditaen_US
dc.contributor.icrauthorStamp, Gordonen_US

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