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dc.contributor.authorMessiou, C
dc.contributor.authorCollins, DJ
dc.contributor.authorMorgan, VA
dc.contributor.authorRobson, MD
dc.contributor.authordeBono, JS
dc.contributor.authorBydder, GM
dc.contributor.authordeSouza, NM
dc.date.accessioned2018-06-26T10:39:50Z
dc.date.issued2010-01
dc.identifier.citationCancer biomarkers : section A of Disease markers, 2010, 7 (4), pp. 211 - 218
dc.identifier.issn1574-0153
dc.identifier.urihttps://repository.icr.ac.uk/handle/internal/1933
dc.identifier.eissn1875-8592
dc.identifier.doi10.3233/cbm-2010-0189
dc.description.abstractIntroduction Ultra Short TE MRI allows signal to be detected from tissues with a very short T2.The aims of this study were to optimize a 2D UTE MRI sequence for imaging and quantification of sclerotic bone metastases, establish T2* values of sclerotic components and investigate the feasibility of using the method to assess changes in T2* of sclerotic metastases and their relation to attenuation values in patients on treatment.Methods Twenty-two subjects were recruited in 3 cohorts. Cohort 1 was used to optimize the 2-D UTE sequence, cohort 2 was used to establish T2* measurements using a range of TEs and cohort 3 was used to assess T2* changes with treatment response and relate them to changes on electron density as measured by CT Hounsfield Units.Results Sagittal 2D UTE MRI of the lumbar spine is feasible demonstrating short T2 components in normal volunteers. In patients with bone metastases secondary to prostate carcinoma T2* can be measured and mean T2* of sclerotic metastases measured with TEs of 0.07, 0.27, 0.47 and 0.67 ms was 8.5 ms.T2* shortened by 20.0% in responders and increased by 24.4% in progressors.Discussion The significant linear relationship between percentage change in T2* as derived from UTE MRI and percentage change in HU from corresponding CT studies is indirect evidence that they are measuring effects of the same process.If the relationship between T2* and electron density holds true in further studies it offers potential for MR guided radiotherapy planning as well as attenuation correction for PET/MRI.
dc.formatPrint
dc.format.extent211 - 218
dc.languageeng
dc.language.isoeng
dc.subjectLumbar Vertebrae
dc.subjectHumans
dc.subjectBone Neoplasms
dc.subjectSclerosis
dc.subjectMagnetic Resonance Imaging
dc.subjectFeasibility Studies
dc.subjectAdult
dc.subjectAged
dc.subjectMiddle Aged
dc.titleQuantifying sclerotic bone metastases with 2D ultra short TE MRI: a feasibility study.
dc.typeJournal Article
rioxxterms.versionofrecord10.3233/cbm-2010-0189
rioxxterms.licenseref.startdate2010-01
rioxxterms.typeJournal Article/Review
dc.relation.isPartOfCancer biomarkers : section A of Disease markers
pubs.issue4
pubs.notesNot known
pubs.organisational-group/ICR
pubs.organisational-group/ICR/Primary Group
pubs.organisational-group/ICR/Primary Group/ICR Divisions
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Clinical Studies
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Clinical Studies/Prostate Cancer Targeted Therapy Group
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Radiotherapy and Imaging
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Radiotherapy and Imaging/Magnetic Resonance
pubs.organisational-group/ICR
pubs.organisational-group/ICR/Primary Group
pubs.organisational-group/ICR/Primary Group/ICR Divisions
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Clinical Studies
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Clinical Studies/Prostate Cancer Targeted Therapy Group
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Radiotherapy and Imaging
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Radiotherapy and Imaging/Magnetic Resonance
pubs.publication-statusPublished
pubs.volume7
pubs.embargo.termsNot known
icr.researchteamProstate Cancer Targeted Therapy Groupen_US
icr.researchteamMagnetic Resonanceen_US
dc.contributor.icrauthorDe Bono, Johannen
dc.contributor.icrauthordeSouza, Nanditaen
dc.contributor.icrauthorMessiou, Christinaen


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