Publications Repository

Publications Repository

View item 
  •   Home
  • ICR Divisions
  • Clinical Studies
  • View item
  • Home
  • ICR Divisions
  • Clinical Studies
  • View item
JavaScript is disabled for your browser. Some features of this site may not work without it.

Targeted therapies in soft tissue sarcomas.

Thumbnail
Date
2010-10
ICR Author
Judson, Ian
Author
Judson, I
Type
Journal Article
Metadata
Show full item record
Abstract
Soft tissue sarcomas are rare cancers but because of their association with characteristic chromosomal translocations and activating mutations they may be particularly susceptible to molecularly targeted therapies. Gastrointestinal stromal tumour (GIST) became the paradigm for targeted therapy in solid tumours owing to the success of imatinib, which has transformed the prognosis in this disease. Translocation-driven tumours have proved harder to target, but the impact of fusion proteins on gene expression is beginning to be understood and may also reveal new targets for therapy, such as insulin-like growth factor 1 receptor, now that effective inhibitors have been discovered. Angiogenesis inhibition also appears to be a promising area for research in sarcomas and many new targets are emerging at the same time as agents capable of investigating them in the clinic are being developed. It is not unrealistic to hope that targeted therapies will play an increasing role in the management of sarcomas in the near future.
URI
https://repository.icr.ac.uk/handle/internal/1938
DOI
https://doi.org/10.1093/annonc/mdq288
Collections
  • Clinical Studies
Subject
Humans
Sarcoma
Soft Tissue Neoplasms
Gastrointestinal Stromal Tumors
Angiogenesis Inhibitors
Somatomedins
Signal Transduction
TOR Serine-Threonine Kinases
Molecular Targeted Therapy
Research team
Sarcoma Clinical Trials
Language
eng
License start date
2010-10
Citation
Annals of oncology : official journal of the European Society for Medical Oncology, 2010, 21 Suppl 7 pp. vii277 - vii280

Browse

All of ICR repositoryICR DivisionsBy issue dateAuthorsTitlesPublication TypesThis collectionBy issue dateAuthorsTitlesPublication Types
  • Login
  • Registered office: The Institute of Cancer Research, 123 Old Brompton Road, London, SW7 3RP
    A Charity, Not for Profit. Company Limited by Guarantee.
    Registered in England No. 534147. VAT Registration No. GB 849 0581 02.