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Conserved Regulation of Cardiac Calcium Uptake by Peptides Encoded in Small Open Reading Frames

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Date
2013
ICR Author
Pearl, Frances
Type
Journal Article
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Abstract
Small open reading frames (smORFs) are short DNA sequences that are able to encode small peptides of less than 100 amino acids. Study of these elements has been neglected despite thousands existing in our genomes. We and others previously showed that peptides as short as 11 amino acids are translated and provide essential functions during insect development. Here, we describe two peptides of less than 30 amino acids regulating calcium transport, and hence influencing regular muscle contraction, in the Drosophila heart. These peptides seem conserved for more than 550 million years in a range of species from flies to humans, in which they have been implicated in cardiac pathologies. Such conservation suggests that the mechanisms for heart regulation are ancient and that smORFs may be a fundamental genome component that should be studied systematically.
URI
https://repository.icr.ac.uk/handle/internal/1982
Collections
  • Cancer Therapeutics
Research team
Computational Biology and Chemogenomics
Language
eng
License start date
2013
Citation
Science, 2013, 341 (6150), pp. 1116 - 1120

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