Now showing items 1-7 of 7

    • Breast cancer risk variants at 6q25 display different phenotype associations and regulate ESR1, RMND1 and CCDC170. 

      Dunning, AM; Michailidou, K; Kuchenbaecker, KB; Thompson, D; French, JD; Beesley, J; Healey, CS; Kar, S; Pooley, KA; Lopez-Knowles, E; Dicks, E; Barrowdale, D; Sinnott-Armstrong, NA; Sallari, RC; Hillman, KM; Kaufmann, S; Sivakumaran, H; Moradi Marjaneh, M; Lee, JS; Hills, M; Jarosz, M; Drury, S; Canisius, S; Bolla, MK; Dennis, J; Wang, Q; Hopper, JL; Southey, MC; Broeks, A; Schmidt, MK; Lophatananon, A; Muir, K; Beckmann, MW; Fasching, PA; Dos-Santos-Silva, I; Peto, J; Sawyer, EJ; Tomlinson, I; Burwinkel, B; Marme, F; Guénel, P; Truong, T; Bojesen, SE; Flyger, H; González-Neira, A; Perez, JIA; Anton-Culver, H; Eunjung, L; Arndt, V; Brenner, H; Meindl, A; Schmutzler, RK; Brauch, H; Hamann, U; Aittomäki, K; Blomqvist, C; Ito, H; Matsuo, K; Bogdanova, N; Dörk, T; Lindblom, A; Margolin, S; Kosma, V-M; Mannermaa, A; Tseng, C-C; Wu, AH; Lambrechts, D; Wildiers, H; Chang-Claude, J; Rudolph, A; Peterlongo, P; Radice, P; Olson, JE; Giles, GG; Milne, RL; Haiman, CA; Henderson, BE; Goldberg, MS; Teo, SH; Yip, CH; Nord, S; Borresen-Dale, A-L; Kristensen, V; Long, J; Zheng, W; Pylkäs, K; Winqvist, R; Andrulis, IL; Knight, JA; Devilee, P; Seynaeve, C; Figueroa, J; Sherman, ME; Czene, K; Darabi, H; Hollestelle, A; van den Ouweland, AMW; Humphreys, K; Gao, Y-T; Shu, X-O; Cox, A; Cross, SS; Blot, W; Cai, Q; Ghoussaini, M; Perkins, BJ; Shah, M; Choi, J-Y; Kang, D; Lee, SC; Hartman, M; Kabisch, M; Torres, D; Jakubowska, A; Lubinski, J; Brennan, P; Sangrajrang, S; Ambrosone, CB; Toland, AE; Shen, C-Y; Wu, P-E; Orr, N; Swerdlow, A; McGuffog, L; Healey, S; Lee, A; Kapuscinski, M; John, EM; Terry, MB; Daly, MB; Goldgar, DE; Buys, SS; Janavicius, R; Tihomirova, L; Tung, N; Dorfling, CM; van Rensburg, EJ; Neuhausen, SL; Ejlertsen, B; Hansen, TVO; Osorio, A; Benitez, J; Rando, R; Weitzel, JN; Bonanni, B; Peissel, B; Manoukian, S; Papi, L; Ottini, L; Konstantopoulou, I; Apostolou, P; Garber, J; Rashid, MU; Frost, D; EMBRACE; Izatt, L; Ellis, S; Godwin, AK; Arnold, N; Niederacher, D; Rhiem, K; Bogdanova-Markov, N; Sagne, C; Stoppa-Lyonnet, D; Damiola, F; GEMO Study Collaborators; Sinilnikova, OM; Mazoyer, S; Isaacs, C; Claes, KBM; De Leeneer, K; de la Hoya, M; Caldes, T; Nevanlinna, H; Khan, S; Mensenkamp, AR; HEBON; Hooning, MJ; Rookus, MA; Kwong, A; Olah, E; Diez, O; Brunet, J; Pujana, MA; Gronwald, J; Huzarski, T; Barkardottir, RB; Laframboise, R; Soucy, P; Montagna, M; Agata, S; Teixeira, MR; kConFab Investigators; Park, SK; Lindor, N; Couch, FJ; Tischkowitz, M; Foretova, L; Vijai, J; Offit, K; Singer, CF; Rappaport, C; Phelan, CM; Greene, MH; Mai, PL; Rennert, G; Imyanitov, EN; Hulick, PJ; Phillips, K-A; Piedmonte, M; Mulligan, AM; Glendon, G; Bojesen, A; Thomassen, M; Caligo, MA; Yoon, S-Y; Friedman, E; Laitman, Y; Borg, A; von Wachenfeldt, A; Ehrencrona, H; Rantala, J; Olopade, OI; Ganz, PA; Nussbaum, RL; Gayther, SA; Nathanson, KL; Domchek, SM; Arun, BK; Mitchell, G; Karlan, BY; Lester, J; Maskarinec, G; Woolcott, C; Scott, C; Stone, J; Apicella, C; Tamimi, R; Luben, R; Khaw, K-T; Helland, Å; Haakensen, V; Dowsett, M; Pharoah, PDP; Simard, J; Hall, P; García-Closas, M; Vachon, C; Chenevix-Trench, G; Antoniou, AC; Easton, DF; Edwards, SL (2016-04)
      We analyzed 3,872 common genetic variants across the ESR1 locus (encoding estrogen receptor α) in 118,816 subjects from three international consortia. We found evidence for at least five independent causal variants, each ...
    • CD248+ stromal cells are associated with progressive chronic kidney disease. 

      Smith, SW; Eardley, KS; Croft, AP; Nwosu, J; Howie, AJ; Cockwell, P; Isacke, CM; Buckley, CD; Savage, COS (2011-07)
      Stromal fibroblasts are the primary cells of the kidney that produce fibrotic matrix. CD248 is a stromal marker expressed on fibroblasts and pericytes within the human kidney. Here, we tested whether CD248 expression in ...
    • Changes in Expression of Genes Representing Key Biologic Processes after Neoadjuvant Chemotherapy in Breast Cancer, and Prognostic Implications in Residual Disease. 

      Klintman, M; Buus, R; Cheang, MCU; Sheri, A; Smith, IE; Dowsett, M (2016-05)
      <h4>Purpose</h4>The primary aim was to derive evidence for or against the clinical importance of several biologic processes in patients treated with neoadjuvant chemotherapy (NAC) by assessing expression of selected genes ...
    • E-cadherin breast tumor expression, risk factors and survival: Pooled analysis of 5,933 cases from 12 studies in the Breast Cancer Association Consortium. 

      Horne, HN; Oh, H; Sherman, ME; Palakal, M; Hewitt, SM; Schmidt, MK; Milne, RL; Hardisson, D; Benitez, J; Blomqvist, C; Bolla, MK; Brenner, H; Chang-Claude, J; Cora, R; Couch, FJ; Cuk, K; Devilee, P; Easton, DF; Eccles, DM; Eilber, U; Hartikainen, JM; Heikkilä, P; Holleczek, B; Hooning, MJ; Jones, M; Keeman, R; Mannermaa, A; Martens, JWM; Muranen, TA; Nevanlinna, H; Olson, JE; Orr, N; Perez, JIA; Pharoah, PDP; Ruddy, KJ; Saum, K-U; Schoemaker, MJ; Seynaeve, C; Sironen, R; Smit, VTHBM; Swerdlow, AJ; Tengström, M; Thomas, AS; Timmermans, AM; Tollenaar, RAEM; Troester, MA; van Asperen, CJ; van Deurzen, CHM; Van Leeuwen, FF; Van't Veer, LJ; García-Closas, M; Figueroa, JD (2018-04-26)
      E-cadherin (CDH1) is a putative tumor suppressor gene implicated in breast carcinogenesis. Yet, whether risk factors or survival differ by E-cadherin tumor expression is unclear. We evaluated E-cadherin tumor immunohistochemistry ...
    • Genome-wide association study of anti-Müllerian hormone levels in pre-menopausal women of late reproductive age and relationship with genetic determinants of reproductive lifespan. 

      Ruth, KS; Soares, ALG; Borges, M-C; Eliassen, AH; Hankinson, SE; Jones, ME; Kraft, P; Nichols, HB; Sandler, DP; Schoemaker, MJ; Taylor, JA; Zeleniuch-Jacquotte, A; Lawlor, DA; Swerdlow, AJ; Murray, A (2019-04)
      Anti-Müllerian hormone (AMH) is required for sexual differentiation in the fetus, and in adult females AMH is produced by growing ovarian follicles. Consequently, AMH levels are correlated with ovarian reserve, declining ...
    • miR-31-3p Expression and Benefit from Anti-EGFR Inhibitors in Metastatic Colorectal Cancer Patients Enrolled in the Prospective Phase II PROSPECT-C Trial. 

      Anandappa, G; Lampis, A; Cunningham, D; Khan, KH; Kouvelakis, K; Vlachogiannis, G; Hedayat, S; Tunariu, N; Rao, S; Watkins, D; Starling, N; Braconi, C; Darvish-Damavandi, M; Lote, H; Thomas, J; Peckitt, C; Kalaitzaki, R; Khan, N; Fotiadis, N; Rugge, M; Begum, R; Rana, I; Bryant, A; Hahne, JC; Chau, I; Fassan, M; Valeri, N (2019-07)
      <h4>Purpose</h4>Anti-EGFR mAbs are effective in the treatment of metastatic colorectal cancer (mCRC) patients. <i>RAS</i> status and tumor location (sidedness) are predictive markers of patients' response to anti-EGFR mAbs. ...
    • A transcriptome-wide association study of 229,000 women identifies new candidate susceptibility genes for breast cancer. 

      Wu, L; Shi, W; Long, J; Guo, X; Michailidou, K; Beesley, J; Bolla, MK; Shu, X-O; Lu, Y; Cai, Q; Al-Ejeh, F; Rozali, E; Wang, Q; Dennis, J; Li, B; Zeng, C; Feng, H; Gusev, A; Barfield, RT; Andrulis, IL; Anton-Culver, H; Arndt, V; Aronson, KJ; Auer, PL; Barrdahl, M; Baynes, C; Beckmann, MW; Benitez, J; Bermisheva, M; Blomqvist, C; Bogdanova, NV; Bojesen, SE; Brauch, H; Brenner, H; Brinton, L; Broberg, P; Brucker, SY; Burwinkel, B; Caldés, T; Canzian, F; Carter, BD; Castelao, JE; Chang-Claude, J; Chen, X; Cheng, T-YD; Christiansen, H; Clarke, CL; NBCS Collaborators; Collée, M; Cornelissen, S; Couch, FJ; Cox, D; Cox, A; Cross, SS; Cunningham, JM; Czene, K; Daly, MB; Devilee, P; Doheny, KF; Dörk, T; Dos-Santos-Silva, I; Dumont, M; Dwek, M; Eccles, DM; Eilber, U; Eliassen, AH; Engel, C; Eriksson, M; Fachal, L; Fasching, PA; Figueroa, J; Flesch-Janys, D; Fletcher, O; Flyger, H; Fritschi, L; Gabrielson, M; Gago-Dominguez, M; Gapstur, SM; García-Closas, M; Gaudet, MM; Ghoussaini, M; Giles, GG; Goldberg, MS; Goldgar, DE; González-Neira, A; Guénel, P; Hahnen, E; Haiman, CA; Håkansson, N; Hall, P; Hallberg, E; Hamann, U; Harrington, P; Hein, A; Hicks, B; Hillemanns, P; Hollestelle, A; Hoover, RN; Hopper, JL; Huang, G; Humphreys, K; Hunter, DJ; Jakubowska, A; Janni, W; John, EM; Johnson, N; Jones, K; Jones, ME; Jung, A; Kaaks, R; Kerin, MJ; Khusnutdinova, E; Kosma, V-M; Kristensen, VN; Lambrechts, D; Le Marchand, L; Li, J; Lindström, S; Lissowska, J; Lo, W-Y; Loibl, S; Lubinski, J; Luccarini, C; Lux, MP; MacInnis, RJ; Maishman, T; Kostovska, IM; Mannermaa, A; Manson, JE; Margolin, S; Mavroudis, D; Meijers-Heijboer, H; Meindl, A; Menon, U; Meyer, J; Mulligan, AM; Neuhausen, SL; Nevanlinna, H; Neven, P; Nielsen, SF; Nordestgaard, BG; Olopade, OI; Olson, JE; Olsson, H; Peterlongo, P; Peto, J; Plaseska-Karanfilska, D; Prentice, R; Presneau, N; Pylkäs, K; Rack, B; Radice, P; Rahman, N; Rennert, G; Rennert, HS; Rhenius, V; Romero, A; Romm, J; Rudolph, A; Saloustros, E; Sandler, DP; Sawyer, EJ; Schmidt, MK; Schmutzler, RK; Schneeweiss, A; Scott, RJ; Scott, CG; Seal, S; Shah, M; Shrubsole, MJ; Smeets, A; Southey, MC; Spinelli, JJ; Stone, J; Surowy, H; Swerdlow, AJ; Tamimi, RM; Tapper, W; Taylor, JA; Terry, MB; Tessier, DC; Thomas, A; Thöne, K; Tollenaar, RAEM; Torres, D; Truong, T; Untch, M; Vachon, C; Van Den Berg, D; Vincent, D; Waisfisz, Q; Weinberg, CR; Wendt, C; Whittemore, AS; Wildiers, H; Willett, WC; Winqvist, R; Wolk, A; Xia, L; Yang, XR; Ziogas, A; Ziv, E; kConFab/AOCS Investigators; Dunning, AM; Pharoah, PDP; Simard, J; Milne, RL; Edwards, SL; Kraft, P; Easton, DF; Chenevix-Trench, G; Zheng, W (2018-07)
      The breast cancer risk variants identified in genome-wide association studies explain only a small fraction of the familial relative risk, and the genes responsible for these associations remain largely unknown. To identify ...