Now showing items 1-5 of 5

    • Evidence that the 5p12 Variant rs10941679 Confers Susceptibility to Estrogen-Receptor-Positive Breast Cancer through FGF10 and MRPS30 Regulation. 

      Ghoussaini, M; French, JD; Michailidou, K; Nord, S; Beesley, J; Canisus, S; Hillman, KM; Kaufmann, S; Sivakumaran, H; Moradi Marjaneh, M; Lee, JS; Dennis, J; Bolla, MK; Wang, Q; Dicks, E; Milne, RL; Hopper, JL; Southey, MC; Schmidt, MK; Broeks, A; Muir, K; Lophatananon, A; Fasching, PA; Beckmann, MW; Fletcher, O; Johnson, N; Sawyer, EJ; Tomlinson, I; Burwinkel, B; Marme, F; Guénel, P; Truong, T; Bojesen, SE; Flyger, H; Benitez, J; González-Neira, A; Alonso, MR; Pita, G; Neuhausen, SL; Anton-Culver, H; Brenner, H; Arndt, V; Meindl, A; Schmutzler, RK; Brauch, H; Hamann, U; Tessier, DC; Vincent, D; Nevanlinna, H; Khan, S; Matsuo, K; Ito, H; Dörk, T; Bogdanova, NV; Lindblom, A; Margolin, S; Mannermaa, A; Kosma, V-M; kConFab/AOCS Investigators; Wu, AH; Van Den Berg, D; Lambrechts, D; Floris, G; Chang-Claude, J; Rudolph, A; Radice, P; Barile, M; Couch, FJ; Hallberg, E; Giles, GG; Haiman, CA; Le Marchand, L; Goldberg, MS; Teo, SH; Yip, CH; Borresen-Dale, A-L; NBCS Collaborators; Zheng, W; Cai, Q; Winqvist, R; Pylkäs, K; Andrulis, IL; Devilee, P; Tollenaar, RAEM; García-Closas, M; Figueroa, J; Hall, P; Czene, K; Brand, JS; Darabi, H; Eriksson, M; Hooning, MJ; Koppert, LB; Li, J; Shu, X-O; Zheng, Y; Cox, A; Cross, SS; Shah, M; Rhenius, V; Choi, J-Y; Kang, D; Hartman, M; Chia, KS; Kabisch, M; Torres, D; Luccarini, C; Conroy, DM; Jakubowska, A; Lubinski, J; Sangrajrang, S; Brennan, P; Olswold, C; Slager, S; Shen, C-Y; Hou, M-F; Swerdlow, A; Schoemaker, MJ; Simard, J; Pharoah, PDP; Kristensen, V; Chenevix-Trench, G; Easton, DF; Dunning, AM; Edwards, SL (2016-10)
      Genome-wide association studies (GWASs) have revealed increased breast cancer risk associated with multiple genetic variants at 5p12. Here, we report the fine mapping of this locus using data from 104,660 subjects from 50 ...
    • Fine-scale mapping of 8q24 locus identifies multiple independent risk variants for breast cancer. 

      Shi, J; Zhang, Y; Zheng, W; Michailidou, K; Ghoussaini, M; Bolla, MK; Wang, Q; Dennis, J; Lush, M; Milne, RL; Shu, X-O; Beesley, J; Kar, S; Andrulis, IL; Anton-Culver, H; Arndt, V; Beckmann, MW; Zhao, Z; Guo, X; Benitez, J; Beeghly-Fadiel, A; Blot, W; Bogdanova, NV; Bojesen, SE; Brauch, H; Brenner, H; Brinton, L; Broeks, A; Brüning, T; Burwinkel, B; Cai, H; Canisius, S; Chang-Claude, J; Choi, J-Y; Couch, FJ; Cox, A; Cross, SS; Czene, K; Darabi, H; Devilee, P; Droit, A; Dork, T; Fasching, PA; Fletcher, O; Flyger, H; Fostira, F; Gaborieau, V; García-Closas, M; Giles, GG; Mervi Grip; Guenel, P; Haiman, CA; Hamann, U; Hartman, M; Miao, H; Hollestelle, A; Hopper, JL; Hsiung, C-N; kConFab Investigators; Ito, H; Jakubowska, A; Johnson, N; Torres, D; Kabisch, M; Kang, D; Khan, S; Knight, JA; Kosma, V-M; Lambrechts, D; Li, J; Lindblom, A; Lophatananon, A; Lubinski, J; Mannermaa, A; Manoukian, S; Le Marchand, L; Margolin, S; Marme, F; Matsuo, K; McLean, C; Meindl, A; Muir, K; Neuhausen, SL; Nevanlinna, H; Nord, S; Børresen-Dale, A-L; Olson, JE; Orr, N; van den Ouweland, AMW; Peterlongo, P; Putti, TC; Rudolph, A; Sangrajrang, S; Sawyer, EJ; Schmidt, MK; Schmutzler, RK; Shen, C-Y; Hou, M-F; Shrubsole, MJ; Southey, MC; Swerdlow, A; Teo, SH; Thienpont, B; Toland, AE; Tollenaar, RAEM; Tomlinson, I; Truong, T; Tseng, C-C; Wen, W; Winqvist, R; Wu, AH; Yip, CH; Zamora, PM; Zheng, Y; Floris, G; Cheng, C-Y; Hooning, MJ; Martens, JWM; Seynaeve, C; Kristensen, VN; Hall, P; Pharoah, PDP; Simard, J; Chenevix-Trench, G; Dunning, AM; Antoniou, AC; Easton, DF; Cai, Q; Long, J (2016-09)
      Previous genome-wide association studies among women of European ancestry identified two independent breast cancer susceptibility loci represented by single nucleotide polymorphisms (SNPs) rs13281615 and rs11780156 at 8q24. ...
    • Genome-wide association study of anti-Müllerian hormone levels in pre-menopausal women of late reproductive age and relationship with genetic determinants of reproductive lifespan. 

      Ruth, KS; Soares, ALG; Borges, M-C; Eliassen, AH; Hankinson, SE; Jones, ME; Kraft, P; Nichols, HB; Sandler, DP; Schoemaker, MJ; Taylor, JA; Zeleniuch-Jacquotte, A; Lawlor, DA; Swerdlow, AJ; Murray, A (2019-04)
      Anti-Müllerian hormone (AMH) is required for sexual differentiation in the fetus, and in adult females AMH is produced by growing ovarian follicles. Consequently, AMH levels are correlated with ovarian reserve, declining ...
    • Identification of independent association signals and putative functional variants for breast cancer risk through fine-scale mapping of the 12p11 locus. 

      Zeng, C; Guo, X; Long, J; Kuchenbaecker, KB; Droit, A; Michailidou, K; Ghoussaini, M; Kar, S; Freeman, A; Hopper, JL; Milne, RL; Bolla, MK; Wang, Q; Dennis, J; Agata, S; Ahmed, S; Aittomäki, K; Andrulis, IL; Anton-Culver, H; Antonenkova, NN; Arason, A; Arndt, V; Arun, BK; Arver, B; Bacot, F; Barrowdale, D; Baynes, C; Beeghly-Fadiel, A; Benitez, J; Bermisheva, M; Blomqvist, C; Blot, WJ; Bogdanova, NV; Bojesen, SE; Bonanni, B; Borresen-Dale, A-L; Brand, JS; Brauch, H; Brennan, P; Brenner, H; Broeks, A; Brüning, T; Burwinkel, B; Buys, SS; Cai, Q; Caldes, T; Campbell, I; Carpenter, J; Chang-Claude, J; Choi, J-Y; Claes, KBM; Clarke, C; Cox, A; Cross, SS; Czene, K; Daly, MB; de la Hoya, M; De Leeneer, K; Devilee, P; Diez, O; Domchek, SM; Doody, M; Dorfling, CM; Dörk, T; Dos-Santos-Silva, I; Dumont, M; Dwek, M; Dworniczak, B; Egan, K; Eilber, U; Einbeigi, Z; Ejlertsen, B; Ellis, S; Frost, D; Lalloo, F; EMBRACE; Fasching, PA; Figueroa, J; Flyger, H; Friedlander, M; Friedman, E; Gambino, G; Gao, Y-T; Garber, J; García-Closas, M; Gehrig, A; Damiola, F; Lesueur, F; Mazoyer, S; Stoppa-Lyonnet, D; behalf of GEMO Study Collaborators; Giles, GG; Godwin, AK; Goldgar, DE; González-Neira, A; Greene, MH; Guénel, P; Haeberle, L; Haiman, CA; Hallberg, E; Hamann, U; Hansen, TVO; Hart, S; Hartikainen, JM; Hartman, M; Hassan, N; Healey, S; Hogervorst, FBL; Verhoef, S; HEBON; Hendricks, CB; Hillemanns, P; Hollestelle, A; Hulick, PJ; Hunter, DJ; Imyanitov, EN; Isaacs, C; Ito, H; Jakubowska, A; Janavicius, R; Jaworska-Bieniek, K; Jensen, UB; John, EM; Joly Beauparlant, C; Jones, M; Kabisch, M; Kang, D; Karlan, BY; Kauppila, S; Kerin, MJ; Khan, S; Khusnutdinova, E; Knight, JA; Konstantopoulou, I; Kraft, P; Kwong, A; Laitman, Y; Lambrechts, D; Lazaro, C; Le Marchand, L; Lee, CN; Lee, MH; Lester, J; Li, J; Liljegren, A; Lindblom, A; Lophatananon, A; Lubinski, J; Mai, PL; Mannermaa, A; Manoukian, S; Margolin, S; Marme, F; Matsuo, K; McGuffog, L; Meindl, A; Menegaux, F; Montagna, M; Muir, K; Mulligan, AM; Nathanson, KL; Neuhausen, SL; Nevanlinna, H; Newcomb, PA; Nord, S; Nussbaum, RL; Offit, K; Olah, E; Olopade, OI; Olswold, C; Osorio, A; Papi, L; Park-Simon, T-W; Paulsson-Karlsson, Y; Peeters, S; Peissel, B; Peterlongo, P; Peto, J; Pfeiler, G; Phelan, CM; Presneau, N; Radice, P; Rahman, N; Ramus, SJ; Rashid, MU; Rennert, G; Rhiem, K; Rudolph, A; Salani, R; Sangrajrang, S; Sawyer, EJ; Schmidt, MK; Schmutzler, RK; Schoemaker, MJ; Schürmann, P; Seynaeve, C; Shen, C-Y; Shrubsole, MJ; Shu, X-O; Sigurdson, A; Singer, CF; Slager, S; Soucy, P; Southey, M; Steinemann, D; Swerdlow, A; Szabo, CI; Tchatchou, S; Teixeira, MR; Teo, SH; Terry, MB; Tessier, DC; Teulé, A; Thomassen, M; Tihomirova, L; Tischkowitz, M; Toland, AE; Tung, N; Turnbull, C; van den Ouweland, AMW; van Rensburg, EJ; Ven den Berg, D; Vijai, J; Wang-Gohrke, S; Weitzel, JN; Whittemore, AS; Winqvist, R; Wong, TY; Wu, AH; Yannoukakos, D; Yu, J-C; Pharoah, PDP; Hall, P; Chenevix-Trench, G; KConFab; AOCS Investigators; Dunning, AM; Simard, J; Couch, FJ; Antoniou, AC; Easton, DF; Zheng, W (2016-06-21)
      Background Multiple recent genome-wide association studies (GWAS) have identified a single nucleotide polymorphism (SNP), rs10771399, at 12p11 that is associated with breast cancer risk.Method We performed a fine-scale ...
    • RAD51B in Familial Breast Cancer. 

      Pelttari, LM; Khan, S; Vuorela, M; Kiiski, JI; Vilske, S; Nevanlinna, V; Ranta, S; Schleutker, J; Winqvist, R; Kallioniemi, A; Dörk, T; Bogdanova, NV; Figueroa, J; Pharoah, PDP; Schmidt, MK; Dunning, AM; García-Closas, M; Bolla, MK; Dennis, J; Michailidou, K; Wang, Q; Hopper, JL; Southey, MC; Rosenberg, EH; Fasching, PA; Beckmann, MW; Peto, J; Dos-Santos-Silva, I; Sawyer, EJ; Tomlinson, I; Burwinkel, B; Surowy, H; Guénel, P; Truong, T; Bojesen, SE; Nordestgaard, BG; Benitez, J; González-Neira, A; Neuhausen, SL; Anton-Culver, H; Brenner, H; Arndt, V; Meindl, A; Schmutzler, RK; Brauch, H; Brüning, T; Lindblom, A; Margolin, S; Mannermaa, A; Hartikainen, JM; Chenevix-Trench, G; kConFab/AOCS Investigators; Van Dyck, L; Janssen, H; Chang-Claude, J; Rudolph, A; Radice, P; Peterlongo, P; Hallberg, E; Olson, JE; Giles, GG; Milne, RL; Haiman, CA; Schumacher, F; Simard, J; Dumont, M; Kristensen, V; Borresen-Dale, A-L; Zheng, W; Beeghly-Fadiel, A; Grip, M; Andrulis, IL; Glendon, G; Devilee, P; Seynaeve, C; Hooning, MJ; Collée, M; Cox, A; Cross, SS; Shah, M; Luben, RN; Hamann, U; Torres, D; Jakubowska, A; Lubinski, J; Couch, FJ; Yannoukakos, D; Orr, N; Swerdlow, A; Darabi, H; Li, J; Czene, K; Hall, P; Easton, DF; Mattson, J; Blomqvist, C; Aittomäki, K; Nevanlinna, H (2016-01)
      Common variation on 14q24.1, close to RAD51B, has been associated with breast cancer: rs999737 and rs2588809 with the risk of female breast cancer and rs1314913 with the risk of male breast cancer. The aim of this study ...