Now showing items 1-3 of 3

    • Endosialin expression in soft tissue sarcoma as a potential marker of undifferentiated mesenchymal cells. 

      Thway, K; Robertson, D; Jones, RL; Selfe, J; Shipley, J; Fisher, C; Isacke, CM (2016-08)
      Background Soft tissue sarcomas are a group of neoplasms with differentiation towards mesenchymal tissue, many of which are aggressive and chemotherapy resistant. Histology and immunoprofiles often overlap with neoplasms ...
    • Endosialin-Expressing Pericytes Promote Metastatic Dissemination. 

      Viski, C; König, C; Kijewska, M; Mogler, C; Isacke, CM; Augustin, HG (2016-09)
      Metastasis is a multistep process that is critically dependent on the interaction of metastasizing tumor cells with cells in the local microenvironment. Within this tumor stroma, vessel-associated pericytes and myofibroblasts ...
    • Pericyte FAK negatively regulates Gas6/Axl signalling to suppress tumour angiogenesis and tumour growth. 

      Lechertier, T; Reynolds, LE; Kim, H; Pedrosa, AR; Gómez-Escudero, J; Muñoz-Félix, JM; Batista, S; Dukinfield, M; Demircioglu, F; Wong, PP; Matchett, KP; Henderson, NC; D'Amico, G; Parsons, M; Harwood, C; Meier, P; Hodivala-Dilke, KM (2020-06-04)
      The overexpression of the protein tyrosine kinase, Focal adhesion kinase (FAK), in endothelial cells has implicated its requirement in angiogenesis and tumour growth, but how pericyte FAK regulates tumour angiogenesis is ...