Proliferation and apoptosis as markers of benefit in neoadjuvant endocrine therapy of breast cancer.
Date
2006-02Author
Dowsett, M
Smith, IE
Ebbs, SR
Dixon, JM
Skene, A
Griffith, C
Boeddinghaus, I
Salter, J
Detre, S
Hills, M
Ashley, S
Francis, S
Walsh, G
A'Hern, R
Type
Journal Article
Metadata
Show full item recordAbstract
The study of changes in proliferation as a marker of treatment benefit during presurgical endocrine treatment of breast cancer has become increasingly popular, particularly using the nuclear marker Ki67, and holds the potential for prioritizing new treatments for full clinical development. There are weakly significant relationships between Ki67 change and clinical response that differ according to data handling. In the neoadjuvant Immediate Preoperative Anastrozole, Tamoxifen, or Combined with Tamoxifen trial, suppression of Ki67 at both 2 and 12 weeks was greater with the aromatase inhibitor anastrozole than with either tamoxifen or the combination of anastrozole and tamoxifen. We report here that absolute values of Ki67 after 2 weeks were also significantly lower with anastrozole than with tamoxifen and the combination. This indicates that it may be possible to make such comparisons using surgical samples only. We argue that these changes in proliferation and concurrent changes in apoptosis may be expected to be more predictive of adjuvant benefit from endocrine therapy than clinical response.
Subject
Humans
Breast Neoplasms
Neoplasms, Hormone-Dependent
Tamoxifen
Nitriles
Triazoles
Ki-67 Antigen
Antineoplastic Agents, Hormonal
Antineoplastic Combined Chemotherapy Protocols
Prognosis
Neoadjuvant Therapy
In Situ Nick-End Labeling
Apoptosis
Cell Proliferation
Female
Biomarkers, Tumor
Anastrozole
Research team
Clinical Trials & Statistics Unit
Medicine (RMH Smith Cunningham)
Endocrinology
Language
eng
License start date
2006-02
Citation
Clinical cancer research : an official journal of the American Association for Cancer Research, 2006, 12 (3 Pt 2), pp. 1024s - 1030s