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dc.contributor.authorMatutes, Een_US
dc.contributor.authorCatovsky, Den_US
dc.date.accessioned2018-07-13T10:51:36Z
dc.date.issued2010-03en_US
dc.identifierhttp://publications.icr.ac.uk/9890/en_US
dc.identifier.citationBEST PRACTICE & RESEARCH CLINICAL HAEMATOLOGY, 2010, 23 (1), pp. 3 - 20en_US
dc.identifier.issn1521-6926en_US
dc.identifier.urihttps://repository.icr.ac.uk/handle/internal/2059
dc.description.abstractThe diagnosis of chronic lymphocytic leukaemia (CLL) is based on clinical and laboratory features. Morphology and immunophenotype are the initial diagnostic investigations. In atypical cases, these tests should be complemented with molecular genetics and/or histology to exclude other B-cell disorders of small lymphocytes. Morphologically, CLL can be classified into typical and atypical. Immunophenotyping is the only method that can establish or confirm the diagnosis as CLL lymphocytes have a distinct immunophenotypic signature. A scoring system compounding the results with a set of markers allows firming up the diagnosis. Other immunological markers such as CD38 and ZAP-70 have an important prognostic impact. Fluorescence in situ hybridization (FISH) analysis, chiefly by detecting 17p (TP53 locus) and 11q (ATM) deletions and mutational status of the IgVH gene, also provides prognostic information and may determine the type of therapy. In atypical CLL, histology and/or molecular genetics may be required to exclude other B-cell disorders. (C) 2010 Elsevier Ltd. All rights reserved.en_US
dc.format.extent3 - 20en_US
dc.publisherELSEVIER SCI LTDen_US
dc.subjectCLL; Diagnosis; Atypical; MBL; Immunophenotype; FISH; Histology;CELL PROLYMPHOCYTIC LEUKEMIA; LYMPHOPROLIFERATIVE DISORDERS; LABORATORY FEATURES; PROGNOSTIC-FACTOR; RICHTER SYNDROME; CD38 EXPRESSION; SCORING SYSTEM; B-CELLS; TRISOMY-12; LYMPHOMAen_US
dc.titleDiagnostic issues in chronic lymphocytic leukaemia (CLL)en_US
dc.typeJournal Article
rioxxterms.licenseref.startdate2010-03en_US
rioxxterms.typeJournal Article/Reviewen_US
dc.relation.isPartOfBEST PRACTICE & RESEARCH CLINICAL HAEMATOLOGYen_US
pubs.issue1en_US
pubs.notesNot knownen_US
pubs.organisational-group/ICR
pubs.organisational-group/ICR/Primary Group
pubs.organisational-group/ICR/Primary Group/ICR Divisions
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Clinical Studies
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Clinical Studies/Molecular Haematology (including Cytogenetics Group and Cell Markers)
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Molecular Pathology
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Molecular Pathology/Molecular Haematology (including Cytogenetics Group and Cell Markers)
pubs.volume23en_US
pubs.embargo.termsNot knownen_US
icr.researchteamMolecular Haematology (including Cytogenetics Group and Cell Markers)en_US
dc.contributor.icrauthorCatovsky, Danielen_US
dc.contributor.icrauthorMatutes, Estellaen_US
dc.contributor.icrauthorWotherspoon, Andrewen_US


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