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dc.date.accessioned2018-07-17T10:05:59Z
dc.date.issued2016-06
dc.identifierhttp://publications.icr.ac.uk/15097/
dc.identifier.citation2016, pp. 550 - 556
dc.identifier.issn1699-048X
dc.identifier.urihttps://repository.icr.ac.uk/handle/internal/2085
dc.description.abstractTesticular germ cell tumors (TGCTs) are the most common solid tumors in young adult men. They constitute a unique pathology because of their embryonic and germ origin and their special behavior. Genetic predisposition, environmental factors involved in their development and genetic aberrations have been under study in many works throughout the last years trying to explain the susceptibility and the transformation mechanism of TGCTs. Despite the high rate of cure in this type of tumors because its particular sensitivity to cisplatin, there are tumors resistant to chemotherapy for which it is needed to find new therapies. In the present work, it has been carried out a literature review on the most important molecular aspects involved in the onset and development of such tumors, as well as a review of the major developments regarding prognostic factors, new prognostic biomarkers and the possibility of new targeted therapies.
dc.format.extent550 - 556
dc.languageeng
dc.language.isoeng
dc.subjectTesticular germ cell tumors Molecular biology Seminoma CARCINOMA IN-SITU GENOME-WIDE ASSOCIATION EMBRYONIC STEM-CELLS SUSCEPTIBILITY LOCI EXPRESSION CANCER RESISTANCE TESTIS PLURIPOTENCY PATHOGENESIS
dc.titleMolecular biology of testicular germ cell tumors
dc.typeJournal Article
rioxxterms.licenseref.startdate2016-06
rioxxterms.typeJournal Article/Review
pubs.notesISI Document Delivery No.: DL6ZJ Times Cited: 0 Cited Reference Count: 43 Gonzalez-Exposito, R. Merino, M. Aguayo, C. 0 SPRINGER-VERLAG ITALIA SRL MILAN CLIN TRANSL ONCOL
pubs.notesNot known
pubs.organisational-group/ICR
pubs.organisational-group/ICR
pubs.embargo.termsNot known
dc.contributor.icrauthorGonzales-Exposito, Reyesen


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