Epidemiology and environmental aspects of marginal zone lymphomas.
Date
2017-03Author
Sriskandarajah, P
Dearden, CE
Type
Journal Article
Metadata
Show full item recordAbstract
Marginal zone lymphomas (MZLs) account for between 5% and 17% of all non-Hodgkin's lymphomas. MZLs consist of 3 different subtypes with extranodal being the most commonly reported, representing 50-70% of MZL, followed by splenic (20%) and nodal (10%). Median age at presentation varies between these lymphoma sub-types, ranging between 50 and 69 years, with an overall greater incidence noted in males compared to females. Given the rarity of these lymphomas, epidemiologic data has been sparse, although it has been suggested the aetiology is multi-factorial including ethnicity and geographical factors. Other reported associations include autoimmune disease and infection, with Helicobacter pylori and Campylobacter psittaci, being the most commonly reported pathogens. Larger population studies are required to investigate the role of these environmental factors further as these can direct the future management of these lymphomas, through the use of more effective targeted treatments.
Collections
Subject
Humans
Helicobacter pylori
Helicobacter Infections
Environmental Exposure
Age of Onset
Aged
Middle Aged
Lymphoma, B-Cell, Marginal Zone
Research team
Molecular Drug Resistance
Language
eng
Date accepted
2016-07-27
License start date
2017-03
Citation
Best practice & research. Clinical haematology, 2017, 30 (1-2), pp. 84 - 91