Epidemiology and environmental aspects of marginal zone lymphomas
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Marginal zone lymphomas (MZLs) account for between 5% and 17% of all non -Hodgkin's lymphomas. MZLs consist of 3 different subtypes with extranodal being the most commonly reported, representing 50-70% of MZL, followed by splenic (20%) and nodal (10%). Median age at presentation varies between these lymphoma sub-types, ranging between 50 and 69 years, with an overall greater incidence noted in males compared to females. Given the rarity of these lymphomas, epidemiologic data has been sparse, although it has been suggested the aetiology is multi-factorial including ethnicity and geographical factors. Other reported associations include autoimmune disease and infection, with Helicobacter pylori and Campylobacter psittaci, being the most commonly reported pathogens. Larger population studies are required to investigate the role of these environmental factors further as these can direct the future management of these lymphomas, through the use of more effective targeted treatments. Crown Copyright (C) 2016 Published by Elsevier Ltd. All rights reserved.
Epidemiology Environmental Marginal zone lymphoma HEPATITIS-C VIRUS B-CELL LYMPHOMA OCULAR ADNEXAL LYMPHOMAS SMALL-INTESTINAL DISEASE NON-HODGKINS-LYMPHOMA GASTRIC MALT LYMPHOMA ALPHA-CHAIN DISEASE PYLORI CAGA PROTEIN PHASE-II TRIAL HELICOBACTER-PYLORI
Molecular Drug Resistance
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BEST PRACTICE & RESEARCH CLINICAL HAEMATOLOGY, 2017, 30 (1-2), pp. 84 - 91
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