Show simple item record

dc.contributor.authorPayne, H
dc.contributor.authorAdamson, A
dc.contributor.authorBahl, A
dc.contributor.authorBorwell, J
dc.contributor.authorDodds, D
dc.contributor.authorHeath, C
dc.contributor.authorHuddart, R
dc.contributor.authorMcMenemin, R
dc.contributor.authorPatel, P
dc.contributor.authorPeters, JL
dc.contributor.authorThompson, A
dc.date.accessioned2018-07-23T13:20:41Z
dc.date.issued2013-11-01
dc.identifier.citationBJU international, 2013, 112 (7), pp. 885 - 897
dc.identifier.issn1464-4096
dc.identifier.urihttps://repository.icr.ac.uk/handle/internal/2114
dc.identifier.eissn1464-410X
dc.identifier.doi10.1111/bju.12291
dc.description.abstract• To review the published data on predisposing risk factors for cancer treatment-induced haemorrhagic cystitis (HC) and the evidence for the different preventive and therapeutic measures that have been used in order to help clinicians optimally define and manage this potentially serious condition. • Despite recognition that HC can be a significant complication of cancer treatment, there is currently a lack of UK-led guidelines available on how it should optimally be defined and managed. • A systematic literature review was undertaken to evaluate the evidence for preventative measures and treatment options in the management of cancer treatment-induced HC. • There is a wide range of reported incidence due to several factors including variability in study design and quality, the type of causal agent, the grading of bleeding, and discrepancies in definition criteria. • The most frequently reported causal factors are radiotherapy to the pelvic area, where HC has been reported in up to 20% of patients, and treatment with cyclophosphamide and bacillus Calmette-Guérin, where the incidence has been reported as up to 30%. • Mesna (2-mercaptoethane sodium sulphonate), hyperhydration and bladder irrigation have been the most frequently used prophylactic measures to prevent treatment-related cystitis, but are not always effective. • Cranberry juice is widely cited as a preventative measure and sodium pentosanpolysulphate as a treatment, although the evidence for both is very limited. • The best evidence exists for intravesical hyaluronic acid as an effective preventative and active treatment, and for hyperbaric oxygen as an equally effective treatment option. • The lack of robust data and variability in treatment strategies used highlights the need for further research, as well as best practice guidance and consensus on the management of HC.
dc.formatPrint
dc.format.extent885 - 897
dc.languageeng
dc.language.isoeng
dc.publisherWILEY
dc.rights.urihttps://creativecommons.org/licenses/by/4.0
dc.subjectHumans
dc.subjectNeoplasms
dc.subjectCystitis
dc.subjectHemorrhage
dc.subjectAntineoplastic Agents
dc.subjectRadiotherapy
dc.subjectIncidence
dc.titleChemical- and radiation-induced haemorrhagic cystitis: current treatments and challenges.
dc.typeJournal Article
dcterms.dateAccepted2013-03-06
rioxxterms.versionofrecord10.1111/bju.12291
rioxxterms.licenseref.urihttps://creativecommons.org/licenses/by-nc-nd/4.0
rioxxterms.licenseref.startdate2013-11
rioxxterms.typeJournal Article/Review
dc.relation.isPartOfBJU international
pubs.issue7
pubs.notesNot known
pubs.organisational-group/ICR
pubs.organisational-group/ICR/Primary Group
pubs.organisational-group/ICR/Primary Group/ICR Divisions
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Radiotherapy and Imaging
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Radiotherapy and Imaging/Clinical Academic Radiotherapy (Huddart)
pubs.organisational-group/ICR
pubs.organisational-group/ICR/Primary Group
pubs.organisational-group/ICR/Primary Group/ICR Divisions
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Radiotherapy and Imaging
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Radiotherapy and Imaging/Clinical Academic Radiotherapy (Huddart)
pubs.publication-statusPublished
pubs.volume112
pubs.embargo.termsNot known
icr.researchteamClinical Academic Radiotherapy (Huddart)
dc.contributor.icrauthorHuddart, Robert


Files in this item

Thumbnail

This item appears in the following collection(s)

Show simple item record

https://creativecommons.org/licenses/by/4.0
Except where otherwise noted, this item's license is described as https://creativecommons.org/licenses/by/4.0