Publications Repository

Publications Repository

View Item 
  •   Home
  • ICR Divisions
  • Radiotherapy and Imaging
  • View Item
  • Home
  • ICR Divisions
  • Radiotherapy and Imaging
  • View Item
JavaScript is disabled for your browser. Some features of this site may not work without it.

Long-term neurologic and peripheral vascular toxicity after chemotherapy treatment of testicular cancer.

Thumbnail
Publication Date
2010-05
ICR Author
Dearnaley, David
Horwich, Alan
Huddart, Robert
Author
Glendenning, JL
Barbachano, Y
Norman, AR
Dearnaley, DP
Horwich, A
Huddart, RA
Type
Journal Article
Metadata
Show full item record
Abstract
<h4>Background</h4>Testicular cancer is curable in the majority of men, and persisting treatment toxicity is a concern. The authors report a cross-sectional study of the long-term effects of chemotherapy (C) on neurologic function and development of Raynaud phenomenon.<h4>Methods</h4>Seven hundred thirty-nine patients who were treated between 1982 and 1992 gave consent to enter the study. Patients were classified according to the receipt of C (n = 384) or no C (n = 355). Patients completed a general health questionnaire and a quality-of-life form (the European Organization for Research and Treatment of Cancer Quality-of-Life C30 questionnaire with testicular module). Symptom scores of 3 or 4 were considered clinically significant. Patients were assessed in the clinic, and clinical history was used to diagnose Raynaud phenomenon (RP) and tinnitus. Examinations included peripheral nerve function testing for light touch and vibration sense. Five hundred seventy-seven patients underwent audiometry.<h4>Results</h4>On physician assessment, peripheral neuropathy and RP were more common after C (21.7% vs 9.1% [P<.001] and 20.3% vs 1.7% [P<.001], respectively). Similar results were obtained for symptom scores (12.5% vs 5.5% [P = .002] and 9.7% vs 3.7% [P<.001], respectively). On multivariate analysis, for peripheral neuropathy, the significant predictors were cisplatin dose, carboplatin dose, and age. For RP, the significant predictor was bleomycin. Significant differences in hearing thresholds were noted at 8000 hertz only and, on multivariate analysis, were related to age, cisplatin dose, and vincristine dose. Auditory symptom scores did not differ between groups.<h4>Conclusions</h4>With long-term follow-up, peripheral neuropathy and RP remained detectable in approximately 20% of patients and caused significant symptoms in 10% of patients. Detectable effects on high frequency remained but caused little symptomatic problem. These effects persisted and were related to the cumulative chemotherapy dose.
URL
https://repository.icr.ac.uk/handle/internal/2135
Collections
  • Radiotherapy and Imaging
  • Closed Research Teams
Version of record
10.1002/cncr.24981
Subject
Microcirculation
Humans
Testicular Neoplasms
Hearing Loss
Tinnitus
Peripheral Nervous System Diseases
Raynaud Disease
Antineoplastic Combined Chemotherapy Protocols
Time
Adolescent
Adult
Aged
Middle Aged
Male
Research team
Clinical Academic Radiotherapy (Dearnaley)
Clinical Academic Radiotherapy (Huddart)
Language
eng
License start date
2010-05
Citation
Cancer, 2010, 116 (10), pp. 2322 - 2331

Browse

All of ICR repositoryICR DivisionsIssue dateAuthorsTitlesSubjectsThis collectionIssue dateAuthorsTitlesSubjects

Statistics

Most popular itemsStatistics by countryMost popular authors
  • Login
  • Registered office: The Institute of Cancer Research, 123 Old Brompton Road, London, SW7 3RP
    A Charity, Not for Profit. Company Limited by Guarantee.
    Registered in England No. 534147. VAT Registration No. GB 849 0581 02.