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dc.contributor.authorDueck, J
dc.contributor.authorKnopf, A-C
dc.contributor.authorLomax, A
dc.contributor.authorAlbertini, F
dc.contributor.authorPersson, GF
dc.contributor.authorJosipovic, M
dc.contributor.authorAznar, M
dc.contributor.authorWeber, DC
dc.contributor.authoraf Rosenschold, PM
dc.date.accessioned2018-07-25T13:37:50Z
dc.date.issued2016-05-01
dc.identifier1
dc.identifier.citationINTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 2016, 95 pp. 534 - 541
dc.identifier.issn0360-3016
dc.identifier.urihttps://repository.icr.ac.uk/handle/internal/2145
dc.identifier.eissn1879-355X
dc.identifier.doi10.1016/j.ijrobp.2015.11.015
dc.description.abstractPurpose: The safe clinical implementation of pencil beam scanning (PBS) proton therapy for lung tumors is complicated by the delivery uncertainties caused by breathing motion. The purpose of this feasibility study was to investigate whether a voluntary breath-hold technique could limit the delivery uncertainties resulting from interfractional motion. Methods and Materials: Data from 15 patients with peripheral lung tumors previously treated with stereotactic radiation therapy were included in this study. The patients had 1 computed tomographic (CT) scan in voluntary breath-hold acquired before treatment and 3 scans during the treatment course. PBS proton treatment plans with 2 fields (2F) and 3 fields (3F), respectively, were calculated based on the planning CT scan and subsequently recalculated on the 3 repeated CT scans. Recalculated plans were considered robust if the V-95% (volume receiving >= 95% of the prescribed dose) of the gross target volume (GTV) was within 5% of what was expected from the planning CT data throughout the simulated treatment. Results: A total of 14/15 simulated treatments for both 2F and 3F met the robustness criteria. Reduced V-95% was associated with baseline shifts (2F, P=.056; 3F, P=.008) and tumor size (2F, P=.025; 3F, P=.025). Smaller tumors with large baseline shifts were also at risk for reduced V95% (interaction term baseline/size: 2F, P=.005; 3F, P=.002). Conclusions: The breath-hold approach is a realistic clinical option for treating lung tumors with PBS proton therapy. Potential risk factors for reduced V95% are small targets in combination with large baseline shifts. On the basis of these results, the baseline shift of the tumor should be monitored (eg, through image guided therapy), and appropriate measures should be taken accordingly. The intrafractional motion needs to be investigated to confirm that the breath-hold approach is robust. (C) 2016 Elsevier Inc. All rights reserved.
dc.format.extent534 - 541
dc.languageeng
dc.language.isoeng
dc.publisherELSEVIER SCIENCE INC
dc.titleRobustness of the Voluntary Breath-Hold Approach for the Treatment of Peripheral Lung Tumors Using Hypofractionated Pencil Beam Scanning Proton Therapy
dc.typeJournal Article
rioxxterms.versionofrecord10.1016/j.ijrobp.2015.11.015
rioxxterms.licenseref.startdate2016-05-01
rioxxterms.typeJournal Article/Review
dc.relation.isPartOfINTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS
pubs.notesaffiliation: Dueck, J (Reprint Author), Paul Scherrer Inst, WBBA 007, CH-5232 Villigen, Switzerland. Dueck, Jenny; Josipovic, Mirjana; Aznar, Marianne; af Rosenschold, Per Munck, Rigshosp, Dept Oncol, Sect Radiotherapy, DK-2100 Copenhagen, Denmark. Dueck, Jenny; Lomax, Antony; Albertini, Francesca; Weber, Damien C., Paul Scherrer Inst, Ctr Proton Therapy, CH-5232 Villigen, Switzerland. Dueck, Jenny; Josipovic, Mirjana; Aznar, Marianne; af Rosenschold, Per Munck, Univ Copenhagen, Niels Bohr Inst, Blegdamsvej 17, DK-2100 Copenhagen, Denmark. Knopf, Antje-Christin, Inst Canc Res & Royal Marsden NHS Fdn Trust, Joint Dept Phys, London, England. Lomax, Antony, ETH, Dept Phys, Zurich, Switzerland. Persson, Gitte F., Rigshosp, Dept Oncol, DK-2100 Copenhagen, Denmark. Aznar, Marianne, Univ Copenhagen, Fac Hlth & Med Sci, Copenhagen, Denmark. Weber, Damien C., Univ Zurich, Zurich, Switzerland. keywords-plus: PERCUTANEOUSLY IMPLANTED MARKERS; RADIATION-THERAPY; RESPIRATORY MOTION; MOBILE TARGETS; RADIOTHERAPY; CANCER; SIMULATION; MARGIN; LIVER; TIME research-areas: Oncology; Radiology, Nuclear Medicine & Medical Imaging web-of-science-categories: Oncology; Radiology, Nuclear Medicine & Medical Imaging author-email: [email protected] researcherid-numbers: Gorgisyan, Jenny/P-6763-2015 Josipovic, Mirjana/H-6905-2018 orcid-numbers: Gorgisyan, Jenny/0000-0001-8879-2257 Josipovic, Mirjana/0000-0001-8288-162X Munck af Rosenschold, Per/0000-0002-5988-8994 number-of-cited-references: 35 times-cited: 9 usage-count-last-180-days: 0 usage-count-since-2013: 7 journal-iso: Int. J. Radiat. Oncol. Biol. Phys. doc-delivery-number: DL1VA unique-id: ISI:000375419500073 da: 2018-07-25
pubs.notesNot known
pubs.organisational-group/ICR
pubs.organisational-group/ICR/Primary Group
pubs.organisational-group/ICR/Primary Group/ICR Divisions
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Radiotherapy and Imaging
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Radiotherapy and Imaging/Radiotherapy Physics Modelling
pubs.organisational-group/ICR
pubs.organisational-group/ICR/Primary Group
pubs.organisational-group/ICR/Primary Group/ICR Divisions
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Radiotherapy and Imaging
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Radiotherapy and Imaging/Radiotherapy Physics Modelling
pubs.volume95
pubs.embargo.termsNot known
icr.researchteamRadiotherapy Physics Modellingen_US
dc.contributor.icrauthorKnopf, Antje-Christinen


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