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dc.contributor.authorter Haar, Gen_US
dc.date.accessioned2018-07-26T09:24:45Z
dc.date.issued2009-08en_US
dc.identifier.citationMedical & biological engineering & computing, 2009, 47 (8), pp. 893 - 900en_US
dc.identifier.issn0140-0118en_US
dc.identifier.urihttps://repository.icr.ac.uk/handle/internal/2154
dc.identifier.eissn1741-0444en_US
dc.identifier.doi10.1007/s11517-009-0507-3en_US
dc.description.abstractThe use of gas-filled microbubbles as ultrasound contrast agents raises potential safety concerns for diagnostic ultrasound imaging. A number of biological effects have been seen in experimental systems, including the induction of physiological response to cardiac exposures (premature ventricular contractions) and damage at a microvascular level (microvascular rupture and petechial haemorrhage). The literature indicates that a mechanical index (MI) of 0.4 represents the threshold above which microvascular bio-effects are seen in in vivo studies. Above this value, the extent of biological effects appears to increase rapidly with both increasing in situ peak negative acoustic pressure amplitude and with contrast agent concentration. While there is no proven evidence of harm resulting from clinical use of these agents, caution is recommended when contrast-enhanced imaging is undertaken.en_US
dc.formatPrint-Electronicen_US
dc.format.extent893 - 900en_US
dc.languageengen_US
dc.language.isoengen_US
dc.subjectAnimalsen_US
dc.subjectHumansen_US
dc.subjectMiceen_US
dc.subjectRatsen_US
dc.subjectContrast Mediaen_US
dc.subjectUltrasonographyen_US
dc.subjectEchocardiographyen_US
dc.subjectMicrobubblesen_US
dc.subjectSafetyen_US
dc.subjectPractice Guidelines as Topicen_US
dc.titleSafety and bio-effects of ultrasound contrast agents.en_US
dc.typeJournal Article
dcterms.dateAccepted2009-06-21en_US
rioxxterms.versionofrecord10.1007/s11517-009-0507-3en_US
rioxxterms.licenseref.startdate2009-08en_US
rioxxterms.typeJournal Article/Reviewen_US
dc.relation.isPartOfMedical & biological engineering & computingen_US
pubs.issue8en_US
pubs.notesNot knownen_US
pubs.organisational-group/ICR
pubs.organisational-group/ICR/Primary Group
pubs.organisational-group/ICR/Primary Group/ICR Divisions
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Radiotherapy and Imaging
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Radiotherapy and Imaging/Therapeutic Ultrasound
pubs.publication-statusPublisheden_US
pubs.volume47en_US
pubs.embargo.termsNot knownen_US
icr.researchteamTherapeutic Ultrasounden_US
dc.contributor.icrauthorTer Haar, Gailen_US
dc.contributor.icrauthorTer Haar, Gailen_US


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