Show simple item record

dc.contributor.authorAlonzi, R
dc.contributor.authorPadhani, AR
dc.contributor.authorMaxwell, RJ
dc.contributor.authorTaylor, NJ
dc.contributor.authorStirling, JJ
dc.contributor.authorWilson, JI
dc.contributor.authord Arcy, JA
dc.contributor.authorCollins, DJ
dc.contributor.authorSaunders, MI
dc.contributor.authorHoskin, PJ
dc.date.accessioned2018-07-26T09:34:09Z
dc.date.issued2009-02-17
dc.identifier4
dc.identifier.citationBRITISH JOURNAL OF CANCER, 2009, 100 pp. 644 - 648
dc.identifier.issn0007-0920
dc.identifier.urihttps://repository.icr.ac.uk/handle/internal/2157
dc.identifier.doi10.1038/sj.bjc.6604903
dc.description.abstractHypoxia has been associated with poor local tumour control and relapse in many cancer sites, including carcinoma of the prostate. This translational study tests whether breathing carbogen gas improves the oxygenation of human prostate carcinoma xenografts in mice and in human patients with prostate cancer. A total of 23 DU145 tumour-bearing mice, 17 PC3 tumour-bearing mice and 17 human patients with prostate cancer were investigated. Intrinsic susceptibility-weighted MRI was performed before and during a period of carbogen gas breathing. Quantitative R(2)* pixel maps were produced for each tumour and at each time point and changes in R(2)* induced by carbogen were determined. There was a mean reduction in R(2)* of 6.4% (P = 0.003) for DU145 xenografts and 5.8% (P = 0.007) for PC3 xenografts. In all, 14 human subjects were evaluable; 64% had reductions in tumour R(2)* during carbogen inhalation with a mean reduction of 21.6% (P = 0.0005). Decreases in prostate tumour R(2)* in both animal models and human patients as a result of carbogen inhalation suggests the presence of significant hypoxia. The finding that carbogen gas breathing improves prostate tumour oxygenation provides a rationale for testing the radiosensitising effects of combining carbogen gas breathing with radiotherapy in prostate cancer patients.
dc.format.extent644 - 648
dc.languageeng
dc.language.isoeng
dc.publisherNATURE PUBLISHING GROUP
dc.titleCarbogen breathing increases prostate cancer oxygenation: a translational MRI study in murine xenografts and humans
dc.typeJournal Article
rioxxterms.versionofrecord10.1038/sj.bjc.6604903
rioxxterms.licenseref.startdate2009-02-17
rioxxterms.typeJournal Article/Review
dc.relation.isPartOfBRITISH JOURNAL OF CANCER
pubs.notesaffiliation: Alonzi, R (Reprint Author), Mt Vernon Hosp, Marie Curie Res Wing, Northwood HA6 2RN, Middx, England. Alonzi, R.; Saunders, M. I.; Hoskin, P. J., Mt Vernon Hosp, Marie Curie Res Wing, Northwood HA6 2RN, Middx, England. Padhani, A. R.; Taylor, N. J., Mt Vernon Hosp, Paul Strickland Scanner Ctr, Northwood HA6 2RN, Middx, England. Maxwell, R. J.; Wilson, J. I., No Inst Canc Res, Sch Med, Newcastle Upon Tyne NE2 4HH, Tyne & Wear, England. Collins, D. J.; Saunders, M. I., Royal Marsden NHS Fdn Trust, CRUK Clin MR Res Grp, Sutton SM2 5PT, Surrey, England. keywords: prostate cancer; carbogen; hypoxia; magnetic resonance imaging; BOLD keywords-plus: PREDICTS RADIATION RESPONSE; HUMAN TUMOR OXYGENATION; CARCINOMA CELL-LINE; MAGNETIC-RESONANCE; MEASUREMENT ERROR; NUDE-MICE; HYPOXIA; BLOOD; HEAD; NECK research-areas: Oncology web-of-science-categories: Oncology author-email: [email protected] funding-acknowledgement: Cancer Research UK [C39/A3987]; Medical Research Council [G0701945] funding-text: Funding: Cancer Research UK (Programme Grant C39/A3987). The funding source had no role in the design of the study, collection, analysis, interpretation of the data, writing of the report or decision to publish. number-of-cited-references: 33 times-cited: 39 usage-count-last-180-days: 0 usage-count-since-2013: 10 journal-iso: Br. J. Cancer doc-delivery-number: 408TB unique-id: ISI:000263456800014 oa: gold_or_bronze da: 2018-07-26
pubs.notesNot known
pubs.organisational-group/ICR
pubs.organisational-group/ICR/Primary Group
pubs.organisational-group/ICR/Primary Group/ICR Divisions
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Radiotherapy and Imaging
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Radiotherapy and Imaging/Magnetic Resonance
pubs.organisational-group/ICR
pubs.organisational-group/ICR/Primary Group
pubs.organisational-group/ICR/Primary Group/ICR Divisions
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Radiotherapy and Imaging
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Radiotherapy and Imaging/Magnetic Resonance
pubs.volume100en_US
pubs.embargo.termsNot known
icr.researchteamMagnetic Resonanceen_US
dc.contributor.icrauthorD'Arcy, Jamesen


Files in this item

FilesSizeFormatView

There are no files associated with this item.

This item appears in the following collection(s)

Show simple item record