Efficacy of low-dose dexamethasone in castration-refractory prostate cancer.
Publication Date
2008-02Author
Venkitaraman, R
Thomas, K
Huddart, RA
Horwich, A
Dearnaley, DP
Parker, CC
Type
Journal Article
Metadata
Show full item recordAbstract
<h4>Objective</h4>To evaluate the prostate-specific antigen (PSA) response rate and duration of PSA response to dexamethasone in patients with castration-refractory prostate cancer (CRPC), as corticosteroids are frequently used as second-line hormonal treatment of CRPC and there is little published evidence concerning the efficacy of low-dose dexamethasone in this setting.<h4>Patients and methods</h4>In all, 102 patients with progressive CRPC received oral dexamethasone (0.5 mg daily) between January 2003 and October 2006. The median pretreatment PSA level was 83 ng/mL. The main endpoint was the PSA response rate according to the PSA Working Group criteria.<h4>Results</h4>In all, 50 patients (49%) had a confirmed PSA response. The median (range) time to PSA progression for the entire cohort was 7.4 (1-28) months. In responders, the median duration of the PSA response was 11.6 (1-24) months.<h4>Conclusion</h4>Low-dose dexamethasone has significant activity in CRPC. Subject to validation with more clinically meaningful endpoints, dexamethasone could become the corticosteroid of choice in the management of CRPC, and its potential for use in combination with novel agents should be explored.
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Subject
Humans
Prostatic Neoplasms
Disease Progression
Dexamethasone
Prostate-Specific Antigen
Antineoplastic Agents, Hormonal
Treatment Outcome
Orchiectomy
Regression Analysis
Retrospective Studies
Cohort Studies
Drug Evaluation
Aged
Aged, 80 and over
Middle Aged
Male
Research team
Clinical Academic Radiotherapy (Dearnaley)
Clinical Academic Radiotherapy (Huddart)
Language
eng
License start date
2008-02
Citation
BJU international, 2008, 101 (4), pp. 440 - 443