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dc.contributor.authorVenkitaraman, R
dc.contributor.authorThomas, K
dc.contributor.authorHuddart, RA
dc.contributor.authorHorwich, A
dc.contributor.authorDearnaley, DP
dc.contributor.authorParker, CC
dc.date.accessioned2018-07-26T10:05:28Z
dc.date.issued2008-02
dc.identifier.citationBJU international, 2008, 101 (4), pp. 440 - 443
dc.identifier.issn1464-4096
dc.identifier.urihttps://repository.icr.ac.uk/handle/internal/2159
dc.identifier.eissn1464-410X
dc.identifier.doi10.1111/j.1464-410x.2007.07261.x
dc.description.abstractObjective To evaluate the prostate-specific antigen (PSA) response rate and duration of PSA response to dexamethasone in patients with castration-refractory prostate cancer (CRPC), as corticosteroids are frequently used as second-line hormonal treatment of CRPC and there is little published evidence concerning the efficacy of low-dose dexamethasone in this setting.Patients and methods In all, 102 patients with progressive CRPC received oral dexamethasone (0.5 mg daily) between January 2003 and October 2006. The median pretreatment PSA level was 83 ng/mL. The main endpoint was the PSA response rate according to the PSA Working Group criteria.Results In all, 50 patients (49%) had a confirmed PSA response. The median (range) time to PSA progression for the entire cohort was 7.4 (1-28) months. In responders, the median duration of the PSA response was 11.6 (1-24) months.Conclusion Low-dose dexamethasone has significant activity in CRPC. Subject to validation with more clinically meaningful endpoints, dexamethasone could become the corticosteroid of choice in the management of CRPC, and its potential for use in combination with novel agents should be explored.
dc.formatPrint-Electronic
dc.format.extent440 - 443
dc.languageeng
dc.language.isoeng
dc.subjectHumans
dc.subjectProstatic Neoplasms
dc.subjectDisease Progression
dc.subjectDexamethasone
dc.subjectProstate-Specific Antigen
dc.subjectAntineoplastic Agents, Hormonal
dc.subjectTreatment Outcome
dc.subjectOrchiectomy
dc.subjectRegression Analysis
dc.subjectRetrospective Studies
dc.subjectCohort Studies
dc.subjectDrug Evaluation
dc.subjectAged
dc.subjectAged, 80 and over
dc.subjectMiddle Aged
dc.subjectMale
dc.titleEfficacy of low-dose dexamethasone in castration-refractory prostate cancer.
dc.typeJournal Article
rioxxterms.versionofrecord10.1111/j.1464-410x.2007.07261.x
rioxxterms.licenseref.startdate2008-02
rioxxterms.typeJournal Article/Review
dc.relation.isPartOfBJU international
pubs.issue4
pubs.notesNot known
pubs.organisational-group/ICR
pubs.organisational-group/ICR/Primary Group
pubs.organisational-group/ICR/Primary Group/ICR Divisions
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Closed research teams
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Closed research teams/Clinical Academic Radiotherapy (Dearnaley)
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Radiotherapy and Imaging
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Radiotherapy and Imaging/Clinical Academic Radiotherapy (Huddart)
pubs.organisational-group/ICR/Primary Group/Royal Marsden Clinical Units
pubs.organisational-group/ICR
pubs.organisational-group/ICR/Primary Group
pubs.organisational-group/ICR/Primary Group/ICR Divisions
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Closed research teams
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Closed research teams/Clinical Academic Radiotherapy (Dearnaley)
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Radiotherapy and Imaging
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Radiotherapy and Imaging/Clinical Academic Radiotherapy (Huddart)
pubs.organisational-group/ICR/Primary Group/Royal Marsden Clinical Units
pubs.publication-statusPublished
pubs.volume101
pubs.embargo.termsNot known
icr.researchteamClinical Academic Radiotherapy (Dearnaley)en_US
icr.researchteamClinical Academic Radiotherapy (Huddart)en_US
dc.contributor.icrauthorHorwich, Alanen
dc.contributor.icrauthorDearnaley, Daviden
dc.contributor.icrauthorHuddart, Roberten
dc.contributor.icrauthorParker, Chrisen


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