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dc.contributor.authorPatterson, DMen_US
dc.contributor.authorPadhani, ARen_US
dc.contributor.authorCollins, DJen_US
dc.identifier.citationNATURE CLINICAL PRACTICE ONCOLOGY, 2008, 5 pp. 220 - 233en_US
dc.description.abstractDiffusion-weighted MRI (DW-MRI) is a functional imaging technique that displays information about the extent and direction of random water motion in tissues. Water movement in tissues is modified by interactions with hydrophobic cellular membranes, intracellular organelles and macromolecules. DW-MRI provides information on extracellular-space tortuosity, tissue cellularity and the integrity of cellular membranes. Images can be sensitive to large or small displacements of water, therefore, macroscopic water flows and microscopic water displacements in the extracellular space can be depicted. Preclinical and clinical data indicate a number of potential roles of DW-MRI in the characterization of malignancy, including determination of lesion aggressiveness and monitoring response to therapy. This Review outlines the biological basis of observations made on DW-MRI and describes how measurements are acquired and quantified, and discusses the interpretation of images and limitations of the technique. The strength of evidence for adoption of DW-MRI as a biomarker for the assessment of tumor response is presented.en_US
dc.format.extent220 - 233en_US
dc.titleTechnology Insight: water diffusion MRI - a potential new biomarker of response to cancer therapyen_US
dc.typeJournal Article
rioxxterms.typeJournal Article/Reviewen_US
pubs.notesaffiliation: Padhani, AR (Reprint Author), Mt Vernon Hosp, Paul Strickland Scanner Ctr, Rickmansworth Rd, Northwood HA6 2RN, Middx, England. Padhani, Anwar R., Mt Vernon Hosp, Paul Strickland Scanner Ctr, Northwood HA6 2RN, Middx, England. Padhani, Anwar R., Synarc Inc, San Francisco, CA USA. Collins, David J., Inst Canc Res, Clin Magnet Resonance Res Grp, Canc Res UK, Sutton, Surrey, England. Collins, David J., Royal Marsden NHS Trust, Sutton, Surrey, England. keywords: apoptosis; biomarker; cellularity; diffusion MRI; dynamic MRI keywords-plus: INTRAVOXEL INCOHERENT MOTION; VASCULAR TARGETING AGENT; EARLY SURROGATE MARKER; FOCAL HEPATIC-LESIONS; WEIGHTED MRI; IN-VIVO; PROSTATE-CANCER; BREAST-CANCER; COEFFICIENT VALUE; RECTAL-CARCINOMA research-areas: Oncology web-of-science-categories: Oncology author-email: [email protected] number-of-cited-references: 87 times-cited: 186 usage-count-last-180-days: 1 usage-count-since-2013: 25 journal-iso: Nat. Clin. Pract. Oncol. doc-delivery-number: 280FY unique-id: ISI:000254412300010 da: 2018-07-26en_US
pubs.notesNot knownen_US
pubs.organisational-group/ICR/Primary Group
pubs.organisational-group/ICR/Primary Group/ICR Divisions
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Radiotherapy and Imaging
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Radiotherapy and Imaging/Magnetic Resonance
pubs.embargo.termsNot knownen_US
icr.researchteamMagnetic Resonanceen_US
dc.contributor.icrauthorCollins, Daviden_US

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