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dc.contributor.authorAl-Lazikani, B
dc.contributor.authorBanerji, U
dc.contributor.authorWorkman, P
dc.date.accessioned2018-07-31T15:18:16Z
dc.date.issued2012-07-10
dc.identifier.citationNature biotechnology, 2012, 30 (7), pp. 679 - 692
dc.identifier.issn1087-0156
dc.identifier.urihttps://repository.icr.ac.uk/handle/internal/2239
dc.identifier.eissn1546-1696
dc.identifier.doi10.1038/nbt.2284
dc.description.abstractOver the past decade, whole genome sequencing and other 'omics' technologies have defined pathogenic driver mutations to which tumor cells are addicted. Such addictions, synthetic lethalities and other tumor vulnerabilities have yielded novel targets for a new generation of cancer drugs to treat discrete, genetically defined patient subgroups. This personalized cancer medicine strategy could eventually replace the conventional one-size-fits-all cytotoxic chemotherapy approach. However, the extraordinary intratumor genetic heterogeneity in cancers revealed by deep sequencing explains why de novo and acquired resistance arise with molecularly targeted drugs and cytotoxic chemotherapy, limiting their utility. One solution to the enduring challenge of polygenic cancer drug resistance is rational combinatorial targeted therapy.
dc.formatElectronic
dc.format.extent679 - 692
dc.languageeng
dc.language.isoeng
dc.subjectHumans
dc.subjectNeoplasms
dc.subjectAntineoplastic Combined Chemotherapy Protocols
dc.subjectCombined Modality Therapy
dc.subjectDrug Design
dc.subjectGenetic Heterogeneity
dc.subjectGenome, Human
dc.subjectMetabolic Networks and Pathways
dc.subjectClinical Trials as Topic
dc.subjectMolecular Targeted Therapy
dc.subjectHigh-Throughput Nucleotide Sequencing
dc.subjectPrecision Medicine
dc.titleCombinatorial drug therapy for cancer in the post-genomic era.
dc.typeJournal Article
rioxxterms.versionofrecord10.1038/nbt.2284
rioxxterms.licenseref.startdate2012-07-10
rioxxterms.typeJournal Article/Review
dc.relation.isPartOfNature biotechnology
pubs.issue7
pubs.notesNot known
pubs.organisational-group/ICR
pubs.organisational-group/ICR/Primary Group
pubs.organisational-group/ICR/Primary Group/ICR Divisions
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Cancer Therapeutics
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Cancer Therapeutics/Computational Biology and Chemogenomics
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Cancer Therapeutics/Medicine Drug Development Unit (de Bono)
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Clinical Studies
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Clinical Studies/Clinical Pharmacology – Adaptive Therapy
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Clinical Studies/Medicine Drug Development Unit (de Bono)
pubs.organisational-group/ICR
pubs.organisational-group/ICR/Primary Group
pubs.organisational-group/ICR/Primary Group/ICR Divisions
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Cancer Therapeutics
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Cancer Therapeutics/Computational Biology and Chemogenomics
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Cancer Therapeutics/Medicine Drug Development Unit (de Bono)
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Clinical Studies
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Clinical Studies/Clinical Pharmacology – Adaptive Therapy
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Clinical Studies/Medicine Drug Development Unit (de Bono)
pubs.publication-statusPublished
pubs.volume30
pubs.embargo.termsNot known
icr.researchteamComputational Biology and Chemogenomicsen_US
icr.researchteamClinical Pharmacology – Adaptive Therapyen_US
icr.researchteamMedicine Drug Development Unit (de Bono)en_US
dc.contributor.icrauthorAl-Lazikani, Bissanen
dc.contributor.icrauthorWorkman, Paulen
dc.contributor.icrauthorBanerji, Udaien
dc.contributor.icrauthorTurner, Lydiaen


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